Antibody Responses in Oral Fluid after Administration of Prophylactic Human Papillomavirus Vaccines
Antibody Responses in Oral Fluid after Administration of Prophylactic Human Papillomavirus Vaccines
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DOI：
10.1086/606026
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发表时间：
2009-11-01
影响因子：
6.4
通讯作者：
Koutsky, Laura A.
中科院分区：
文献类型：
--
作者：
Rowhani-Rahbar, Ali;Carter, Joseph J.;Koutsky, Laura A.
我们试图确定是否可以使用口腔液来评估血清人乳头瘤病毒（HPV）抗体状态，招募妇女谁收到了预防性HPV-16疫苗在一个新的后续研究。在预防性HPV-6/11/16/18疫苗在美国获得许可后，我们将其给予同意的参与者。以血清学检查结果作为参考标准，四价疫苗接种前和接种后口服液的敏感性分别为49.6%（95% CI，42.0%-57.3%）和100%（95% CI，92.0%-100%）。口腔液可能有潜力在未来用于预防性HPV疫苗的监测。
We sought to determine whether oral fluid can be used to assess serum human papillomavirus (HPV) antibody status by enrolling women who had received a prophylactic HPV-16 vaccine in a new follow-up study. After the prophylactic HPV-6/11/16/18 vaccine was licensed in the United States, we administered it to consenting participants. With serologic findings used as the reference standard, The sensitivity of oral fluid was 49.6% (95% confidence interval [CI], 42.0%-57.3%) before and 100% (95% CI, 92.0%-100%) after administration of the quadrivalent vaccine. Oral fluid may have the potential to be used for monitoring of prophylactic HPV vaccines in the future.