SALIVARY CORTISOL - A PRACTICAL METHOD FOR EVALUATION OF ADRENAL-FUNCTION
SALIVARY CORTISOL - A PRACTICAL METHOD FOR EVALUATION OF ADRENAL-FUNCTION
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DOI：
10.1016/0006-3223(88)90284-3
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发表时间：
1988-02-15
影响因子：
10.6
通讯作者：
POST, RM
中科院分区：
文献类型：
--
作者：
KAHN, JP;RUBINOW, DR;POST, RM
唾液皮质醇是一种简单、无创、无压力的测量方法，可以极大地促进精神疾病患者下丘脑-垂体-肾上腺轴活动的纵向研究。通过对市售放射免疫测定试剂盒的轻微修改，我们研究了不同条件下唾液皮质醇的稳定性，以及基础昼夜节律条件下血浆和唾液皮质醇与刺激（CRH）和抑制（地塞米松）之间的关系。我们观察到唾液皮质醇在室温下不离心是相当稳定的，唾液和血浆皮质醇值高度相关。此外，我们观察到唾液和血浆皮质醇在昼夜节律和超昼夜波动中的密切对应。唾液皮质醇对羊和人CRH的反应与血浆皮质醇的反应相似，但幅度更大。最后，采用血浆标准作为标准，唾液测量确定了48%的非抑制性地塞米松抑制试验（DSTs）和97%的抑制性DSTs。
Salivary cortisol represents a simple, noninvasive, stress-free measure that can greatly facilitate the longitudinal study of hypothalamic-pituitary-adrenal axis activity in patients with psychiatric disorders. By means of a slight modification of a commercially available radioimmunoassay kit, we studied the stability of salivary cortisol under different conditions, as well as the relationship between plasma and salivary cortisol under basal circadian conditions and following stimulation (CRH) and suppression (dexamethasone). We observed that salivary cortisol was quite stable at room temperature without centrifugation and that salivary and plasma cortisol values were highly correlated. Additionally, we observed a close correspondence in circadian and ultradian fluctuations in salivary and plasma cortisol. The salivary cortisol response to ovine and human CRH was similar to that observed with plasma cortisol, but was greater in magnitude. Finally, employing a plasma criterion as the standard, salivary measures identified 48% of the nonsuppressed Dexamethasone Suppression Tests (DSTs) and 97% of the suppressed DSTs.