The pNNx files: re-examining a widely used heart rate variability measure
The pNNx files: re-examining a widely used heart rate variability measure
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DOI：
10.1136/heart.88.4.378
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发表时间：
2002-10-01
期刊：
影响因子：
5.7
通讯作者：
Goldberger, AL
中科院分区：
文献类型：
--
作者：
Mietus, JE;Peng, CK;Goldberger, AL
目的：通过确定其他阈值与区分生理和病理组时常用的 50 ms 阈值的比较，重新检查标准 pNN50 心率变异性 (HRV) 统计数据。设计：Halter 监测数据库的回顾性分析。受试者：72 名健康受试者和 43 名充血性心力衰竭 (CHF) 受试者之间 HRV 数据的比较； 72 名健康受试者在睡眠和清醒状态之间的变化；以及 20 名年轻人和 20 名健康老年人受试者。主要结果指标：使用家庭区分不同群体的概率值。 pNN 值范围从 pNN4 到 pNN100。结果：对于所有三个比较，pNN 值远小于 50 毫秒，始终提供更好的组间分离。对于正常组与 CHF 组，pNN12 的 p < 10(-13) 相对于 pNN50 的 p < 10(-4)；对于睡眠组与清醒组，pNN 12 的 p < 10(-21) 相对于 pNN50 的 p < 10(-10)；对于年轻组与老年组，pNN28 的 p < 10(-6) 相对于 pNN50 的 p < 10(-4)。此外，对于老年健康受试者与年轻 CHF 患者的亚组，pNN20 的 p < 0.007 对比 pNN50 的 p < 0.17；对于纽约心脏协会功能性 I-II 级 CHF 与 III-IV 级的亚组，pNN10 的 p < 0.04，而 pNN50 的 p < 0.13。结论：pNN50 只是 HRV 统计的一般 pNNx 系列的一个成员。通过使用低至 20 毫秒或更小的 pNN 阈值（而不是标准的 50 毫秒阈值），可以增强区分各种正常和病理状况。
Objective: To re-examine the standard pNN50 heart rate variability (HRV) statistic by determining how other thresholds compare with the commonly adopted 50 ms threshold in distinguishing physiological and pathological groups.Design: Retrospective analysis of Halter monitor databases.Subjects: Comparison of HRV data between 72 healthy subjects and 43 with congestive heart failure (CHF); between sleeping and waking states in the 72 healthy subjects; and between 20 young and 20 healthy elderly subjects.Main outcome measures: Probability values for discriminating between groups using a family of. pNN values ranging from pNN4 to pNN100.Results: For all three comparisons, pNN values substantially less than 50 ms consistently provided better separation between groups. For the normal versus CHF groups, p < 10(-13) for pNN12 versus p < 10(-4) for pNN50; for the sleeping versus awake groups, p < 10(-21) for pNN 12 versus p < 10(-10) for pNN50; and for the young versus elderly groups, p < 10(-6) for pNN28 versus p < 10(-4) for pNN50. In addition, for the subgroups of elderly healthy subjects versus younger patients with CHF, p < 0.007 for pNN20 versus p < 0.17 for pNN50; and for the subgroup of New York Heart Association functional class I-II CHF versus class III-IV, p < 0.04 for pNN10 versus p < 0.13 for pNN50.Conclusions: pNN50 is only one member of a general pNNx family of HRV statistics. Enhanced discrimination between a variety of normal and pathological conditions is obtained by using pNN thresholds as low as 20 ms or less rather than the standard 50 ms threshold.