pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation.
pRB, p107 and p130 as transcriptional regulators: role in cell growth and differentiation.
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DOI：
10.1007/978-1-4615-5371-7_13
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
X. Mayol;X. Graña
中科院分区：
文献类型：
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作者：
X. Mayol;X. Graña
由细胞周期蛋白/CDK全酶组成的哺乳动物细胞周期引擎通过调节（至少部分地）两种类型基因的转录来控制整个细胞周期的进程：其蛋白质产物是DNA代谢所需的基因和其蛋白质产物参与细胞周期控制的基因。在细胞周期蛋白/CDK的靶点中，有一个负生长调节因子家族，统称为口袋蛋白。这个口袋蛋白家族包括视网膜母细胞瘤肿瘤抑制基因pRB的产物以及功能和结构相关的蛋白质p107和p130。在这篇综述中，口袋蛋白被认为是调节细胞生长和分化的机制进行了讨论。
The mammalian cell cycle engine, which is composed of cyclin/CDK holoenzymes, controls the progression throughout the cell cycle by regulating, at least in part, the transcription of two types of genes: genes whose protein products are required for DNA metabolism and genes whose protein products are involved in cell cycle control. Among the targets of cyclin/CDKs, there is a family of negative growth regulators collectively known as pocket proteins. This family of pocket proteins includes the product of the retinoblastoma tumor suppressor gene, pRB and the functionally and structurally related proteins p107 and p130. In this review, the mechanisms by which pocket proteins are thought to regulate cell growth and differentiation are discussed.