Interhemispheric compensation: A hypothesis of TMS-induced effects on language-related areas
Interhemispheric compensation: A hypothesis of TMS-induced effects on language-related areas
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DOI：
10.1016/j.eurpsy.2007.10.012
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发表时间：
2008-06-01
影响因子：
7.8
通讯作者：
Martinot, Jean-Luc
中科院分区：
文献类型：
--
作者：
Andoh, Jamila;Martinot, Jean-Luc
重复经颅磁刺激（rTMS）应用于负责语言处理的大脑区域，用于减少精神分裂症患者潜在的幻听，并研究语言相关区域的功能组织。然而，不同研究和不同受试者之间的效应差异显著。此外，rTMS的作用机制知之甚少。在这里，我们回顾了可能影响rTMS诱导效应的脑结构和功能组织相关的不同因素。然后，通过与失语症研究的类比，以及失语症恢复后左右半球的可塑性适应性变化。提出了一个关于语言相关区域上的rTMS机制的假设（例如Wernicke，Broca）。我们认为，rTMS在语言相关区域引起的局部干扰可能类似于失语性中风，并可能导致与虚拟损伤相关区域的功能重组，以恢复语言。(c)2008年，Elsevier Masson SAS。All rights reserved.
Repetitive transcranial magnetic stimulation (rTMS) applied over brain regions responsible for language processing is used to curtail potentially auditory hallucinations in schizophrenia patients and to investigate the functional organisation of langua ge-related areas. Variability of effects is, however, marked across studies and between subjects. Furthermore, the mechanisms of action of rTMS are poorly understood.Here, we reviewed different factors related to the structural and functional organisation of the brain that might influence rTMS-indUced effects. Then, by analogy with aphasia studies, and the plastic-adaptive changes in both the left and right hemispheres following aphasia recovery. a hypothesis is proposed about rTMS mechanisms over language-related areas (e.g. Wernicke, Broca). We proposed that the local interference induced by rTMS in language- re I ated areas might be analogous to aphasic stroke and might lead to a functional reorganisation in areas connected to the virtual lesion for language recovery. (c) 2008 Elsevier Masson SAS. All rights reserved.