TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing.
TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing.
复制标题
动脉化学感受器中的任务通道及其在氧气和酸感应中的作用。
DOI：
10.1007/s00424-015-1689-1
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Buckler KJ
中科院分区：
文献类型：
--
作者：
Buckler KJ
动脉化学感受器通过向大脑提供有关血氧、二氧化碳和ph值的信息，在心血管控制中起着至关重要的作用。主要的化学感受器，颈动脉体，由感觉（1型）细胞组成，它们通过去极化受体电位对缺氧或酸中毒作出反应，进而激活电压门控钙进入、神经分泌和邻近传入神经的兴奋。受体电位是通过抑制twik相关的酸敏感K+通道1和3 （TASK1/TASK3）异二聚体通道产生的，这些通道通常维持细胞的静息膜电位。这些通道被认为直接受到酸中毒的抑制。然而，氧敏感性可能源于代谢信号通路。颈动脉小体、分离的1型细胞以及在1型细胞中发现的所有形式的TASK通道对线粒体代谢抑制剂高度敏感。此外，1型细胞TASK通道被毫摩尔水平的MgATP激活。除了在化学刺激转导中的作用外，1型细胞TASK通道还涉及许多神经分泌/旁分泌信号分子（包括腺苷、GABA和5 -羟色胺）对化学受体功能的调节。它们也可能有助于介导某些全身麻醉引起的急性缺氧通气反应的抑制。因此，TASK通道活动的调节是控制化学感受器兴奋性的关键机制。这不仅具有重要的生理意义，而且可能为治疗与化学受体功能障碍相关的心肺疾病提供一种治疗策略。
Arterial chemoreceptors play a vital role in cardiorespiratory control by providing the brain with information regarding blood oxygen, carbon dioxide, and pH. The main chemoreceptor, the carotid body, is composed of sensory (type 1) cells which respond to hypoxia or acidosis with a depolarising receptor potential which in turn activates voltage-gated calcium entry, neurosecretion and excitation of adjacent afferent nerves. The receptor potential is generated by inhibition of Twik-related acid-sensitive K+ channel 1 and 3 (TASK1/TASK3) heterodimeric channels which normally maintain the cells’ resting membrane potential. These channels are thought to be directly inhibited by acidosis. Oxygen sensitivity, however, probably derives from a metabolic signalling pathway. The carotid body, isolated type 1 cells, and all forms of TASK channel found in the type 1 cell, are highly sensitive to inhibitors of mitochondrial metabolism. Moreover, type1 cell TASK channels are activated by millimolar levels of MgATP. In addition to their role in the transduction of chemostimuli, type 1 cell TASK channels have also been implicated in the modulation of chemoreceptor function by a number of neurocrine/paracrine signalling molecules including adenosine, GABA, and serotonin. They may also be instrumental in mediating the depression of the acute hypoxic ventilatory response that occurs with some general anaesthetics. Modulation of TASK channel activity is therefore a key mechanism by which the excitability of chemoreceptors can be controlled. This is not only of physiological importance but may also offer a therapeutic strategy for the treatment of cardiorespiratory disorders that are associated with chemoreceptor dysfunction.
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影响因子：
5.5
作者：
Buckler, KJ;Vaughan-Jones, RD
通讯作者：
Vaughan-Jones, RD
DOI：
10.1016/j.bbrc.2004.07.081
发表时间：
2004-09-10
影响因子：
3.1
作者：
Buttigieg, J;Nurse, CA
通讯作者：
Nurse, CA
影响因子：
11.4
作者：
Chemin, J;Girard, C;Lazdunski, M
通讯作者：
Lazdunski, M
影响因子：
5.5
作者：
Buckler, KJ;Honoré, E
通讯作者：
Honoré, E
影响因子：
5.5
作者：
Conde, S. V.;Obeso, A.;Gonzalez, C.
通讯作者：
Gonzalez, C.