Cleft palate and velopharyngeal dysfunction
Cleft palate and velopharyngeal dysfunction
复制标题
腭裂和腭咽功能障碍
DOI：
--
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
B. Sommerlad
中科院分区：
文献类型：
--
作者：
S. Cugno;B. Sommerlad
摘要腭裂是由胚胎发育7周至12周的腭架融合异常所致。腭裂可能是孤立发生的，也可能是命名序列或综合征的组成部分。最常见的异常是Pierre Robin序列，包括小颌下垂、舌下垂和呼吸窘迫。腭裂也可发生在许多综合征中，包括van der Woude、Stickler、Treacher Collins和Apert综合征，以及眼-耳-脊椎谱。人们普遍认为，腭部修复应该在12个月前完成。腭咽闭合不全可能是腭裂修复后的结果，也可能是显性或隐匿性粘膜下裂的前兆。在22q11.2缺失(瓣膜面)综合征中，在没有裂隙证据的情况下识别出隐匿性黏膜下腭裂或腭咽闭合功能障碍是常见的。腭咽闭合功能障碍的治疗包括腭裂成形术、腭裂成形术、咽瓣成形术、括约肌咽成形术或假体修复。
Abstract Cleft palate results from an aberration of fusion of the palatal shelves between weeks 7 and 12 of embryonic development. Cleft palate may occur in isolation or as a component of a named sequence or syndrome. The most commonly associated anomaly is Pierre Robin sequence, which includes micrognathia, glossoptosis, and respiratory distress. Cleft palate can also occur in a number of syndromes, including van der Woude, Stickler, Treacher Collins, and Apert syndromes, as well as oculo-auriculo-vertebral spectrum. There is general agreement that palate repair should be effected before 12 months of age. Velopharyngeal insufficiency may result following cleft palate repair or may herald the presence of an overt or occult submucous cleft palate. Identification of an occult submucous cleft palate or velopharyngeal dysfunction without evidence of a cleft is common in 22q11.2 deletion (velocardiofacial) syndrome. Treatment of velopharyngeal dysfunction includes palate re-repair with intravelar veloplasty, Furlow palatoplasty, pharyngeal flap, sphincter pharyngoplasty, or prosthetics.
影响因子：
158.5
作者：
Zucchero, TM;Cooper, ME;Murray, JC
通讯作者：
Murray, JC