Association of leptin with orthostatic blood pressure changes in Parkinson's disease
Association of leptin with orthostatic blood pressure changes in Parkinson's disease
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DOI：
10.1002/mds.26678
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发表时间：
2016-09-01
影响因子：
8.6
通讯作者：
Sobue, Gen
中科院分区：
文献类型：
--
作者：
Nakamura, Tomohiko;Suzuki, Masashi;Sobue, Gen
Leptin参与血压调节，但尚无研究评价Leptin在PD患者立位应激时血压变化中的作用。本研究的目的是确定血浆瘦素水平是否影响PD患者的立位血压变化。结果在直立倾斜试验中，帕金森病患者的血压变化与基线和60度直立倾斜时的瘦素水平密切相关，而在对照组中没有相关性。多元回归分析还显示瘦素水平与立位血压变化有关。结论PD患者直立倾斜试验中瘦素水平降低可能与立位性低血压有关。(C)2016国际帕金森病和运动障碍协会
IntroductionLeptin is involved in the regulation of blood pressure; however, no studies have evaluated the role of leptin in blood pressure changes during orthostatic stress in PD patients. The aim of this study was to determine whether plasma leptin levels influence orthostatic blood pressure changes in PD patients.MethodsWe enrolled 55 patients and 25 age-matched healthy controls in this study. Associations between head-up tilt test measurements and leptin levels were evaluated.ResultsSystolic blood pressure changes during the head-up tilt tests were strongly correlated with leptin levels at baseline and at a 60-degree head-up tilt in PD patients, but not in control subjects. Multiple regression analysis also demonstrated that leptin levels were associated with orthostatic blood pressure changes.ConclusionThese observations suggest that low leptin levels may be associated with orthostatic hypotension during the head-up tilt test in patients with PD. (c) 2016 International Parkinson and Movement Disorder Society