Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinoma
Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinoma
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DOI：
10.1016/j.humpath.2007.06.004
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发表时间：
2008-02-01
期刊：
影响因子：
3.3
通讯作者：
Goodman, Zachary D.
中科院分区：
文献类型：
--
作者：
Abdul-Al, Hala M.;Makhlouf, Hala R.;Goodman, Zachary D.
磷脂酰肌醇蛋白聚糖 3 是一种癌胎儿抗原，作为肝细胞癌的辅助诊断显示出巨大的前景。为了研究磷脂酰肌醇蛋白聚糖 3 是否也可能出现在非肿瘤性肝细胞中，我们对 60 个慢性丙型肝炎活检组织进行了免疫染色，其中 30 个具有低活性，30 个具有高活性。在 30 名高级别组中，有 25 名（83.6%）检测到磷脂酰肌醇蛋白聚糖 3 免疫反应性，但在低级别组中没有检测到。在 20% 的阳性病例中，磷脂酰肌醇蛋白聚糖 3 对超过 25% 的肝细胞产生强细胞质染色，可能导致肝细胞癌的误诊。当存在活动性坏死性炎症性疾病时，病理学家应意识到这种现象，并在解释疑似肝细胞癌的活检或其他标本时谨慎行事。 (C) 2008 年，爱思唯尔公司出版。
Glypican 3 is an oncofetal antigen that shows great promise as an adjunct to the diagnosis of hepatocellular carcinoma. To investigate whether glypican 3 might also appear in nonneoplastic liver cells, we performed immunostains on 60 biopsies of chronic hepatitis C, 30 with low-grade activity and 30 with high-grade activity. Glypican 3 immunoreactivity was detected in 25 (83.6%) of 30 in the high-grade but in none in the low-grade group. In 20% of the positive cases, glypican 3 produced strong cytoplasmic staining of more than 25% of hepatocytes and could potentially lead to a misdiagnosis of hepatocellular carcinoma. Pathologists should be aware of this phenomenon and exercise caution in interpreting biopsies or other specimens of suspected hepatocellular carcinoma when active necroinflammatory disease is present. (C) 2008 Published by Elsevier Inc.