Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.
Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.
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DOI：
10.1016/s0021-9258(18)53485-2
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发表时间：
1993-03
期刊：
影响因子：
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通讯作者：
A. Campagnoni;T. Pribyl;C. Campagnoni;K. Kampf;S. Amur‐Umarjee;C. Landry;V. Handley;S. Newman;B. Garbay;K. Kitamura
中科院分区：
文献类型：
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作者：
A. Campagnoni;T. Pribyl;C. Campagnoni;K. Kampf;S. Amur‐Umarjee;C. Landry;V. Handley;S. Newman;B. Garbay;K. Kitamura
我们已经确定了一个新的转录单位105个酶（称为Golli-mbp基因），包括小鼠髓鞘碱性蛋白（MBP）基因。该基因内的三个独特外显子被选择性地剪接成MBP外显子和内含子，以产生在个体发育调控下的MBP基因相关mRNA家族。这些mRNA在分化的进行性阶段在少突胶质细胞谱系的细胞内暂时表达。因此，MBP基因是一个更复杂的基因结构的一部分，其产物可能在髓鞘形成前的少突胶质细胞分化中发挥作用。一种编码与MBP抗原相关的蛋白质的Golli-mbp mRNA也在脾脏和其他非神经组织中表达。
We have identified a novel transcription unit of 105 kilobases (called the Golli-mbp gene) that encompasses the mouse myelin basic protein (MBP) gene. Three unique exons within this gene are alternatively spliced into MBP exons and introns to produce a family of MBP gene-related mRNAs that are under individual developmental regulation. These mRNAs are temporally expressed within cells of the oligodendrocyte lineage at progressive stages of differentiation. Thus, the MBP gene is a part of a more complex gene structure, the products of which may play a role in oligodendrocyte differentiation prior to myelination. One Golli-mbp mRNA that encodes a protein antigenically related to MBP is also expressed in the spleen and other non-neural tissues.