RAGWEED HAY-FEVER - GENETIC-CONTROL AND LINKAGE TO HL-A HAPLOTYPES
RAGWEED HAY-FEVER - GENETIC-CONTROL AND LINKAGE TO HL-A HAPLOTYPES
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DOI：
10.1126/science.178.4066.1201
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
FOTINO, M
中科院分区：
文献类型：
--
作者：
LEVINE, BB;STEMBER, RH;FOTINO, M
临床豚草花粉症（花粉热）和特异性抗原E（豚草花粉提取物的主要纯化蛋白抗原）的IgE抗体产生密切相关的HL-A单倍型在连续几代的7个家庭。HL-A相关的IgE抗体反应性是抗原特异性的，并延伸到IgG抗体的产生。这些数据表明，特异性抗原E的免疫应答（Ir）基因是必要的，但不足以发展花粉热。这似乎是人类中Ir基因的第一个文件。
Clinical ragweed pollenosis (hay fever) and IgE antibody production specific for antigen E (the major purified protein antigen from ragweed pollen extract) correlated closely with HL-A haplotypes in successive generations of seven families. HL-A associated IgE antibody responsiveness was antigen specific and extended also to IgGantibody production. These data indicate an immune response (Ir) gene specific for antigen E necessary but not sufficient for the development of hay fever. This appears to be the first documentation of an Ir gene in man.