Human biodistribution and dosimetry of the PET radioligand [¹¹C]flumazenil (FMZ).
Human biodistribution and dosimetry of the PET radioligand [¹¹C]flumazenil (FMZ).
复制标题
PET 放射性配体 [11C]氟马西尼 (FMZ) 的人体生物分布和剂量测定。
DOI：
10.1007/s11307-011-0478-2
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发表时间：
2012
影响因子：
3.1
通讯作者：
Frankle,WGordan
中科院分区：
文献类型：
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作者：
Laymon,CharlesM;Narendran,Rajesh;Mason,NealeS;Carney,JonathanP;Lopresti,BrianJ;Mathis,ChesterA;Mountz,JamesM;Sashin,Donald;Frankle,WGordan
目的我们测量全身分布的静脉注射[11 C]氟马西尼（FMZ）作为一个函数的时间在成人subjects. Procedures的吸收辐射doses 770 MBq的[11 C]FMZ（标称）注射后，每个6名受试者进行了9个连续的全身PET扫描。使用PET衰减和发射图像确定了12个源器官。根据9次PET扫描的顺序，确定每个器官内的活动作为时间的函数。对源器官时间活性曲线进行积分，并通过注射剂量进行标准化，以产生无排泄情况下的源器官停留时间。单独的膀胱驻留时间计算的情况下，1和2小时排尿间隔。使用源器官停留时间作为输入，程序OLINDA/EXM（Stabin et al. in J Nucl Med. 46：1023-1027，2005）用于对各种身体器官和全身进行剂量学计算。结果对于无排泄情况，注射[11 C]FMZ的平均全身辐射当量剂量为3.02 × 10− 3 mSv/MBq。平均有效剂量和有效剂量当量分别为7.57 × 10− 3和1.12 × 10− 2 mSv MBq−1。接受最高等效剂量的器官是膀胱壁，平均为6.32 × 10− 2 mSv MBq− 1。给予少于790 MBq（21 mCi）的[11 C]FMZ产生（无排泄模型）器官等效剂量低于50 mSv [美国法规规定的研究性研究单次剂量限值（21 CFR 361.1）除造血器官、生殖腺或眼睛透镜以外的身体器官]所有器官。给予790 MBq FMZ剂量的造血器官和性腺的等效剂量远低于21 CFR 361.1规定的30 mSv限值。此外，低于1320 MBq（35.7 mCi）的剂量产生的有效剂量[国际辐射防护委员会（ICRP）60组织加权方案]低于10 mSv，这是ICRP IIb（轻度至中度）风险类别限值。
PurposeWe measure the whole-body distribution of IV injected [11C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses.ProceduresAfter injection with 770 MBq of [11C]FMZ (nominal), each of six subjects underwent nine consecutive whole body PET scans. Twelve source organs were identified using PET attenuation and emission images. Activity within each organ as a function of time was determined from the sequence of the nine PET scans. Source organ time activity curves were integrated and normalized by the injected dose to yield source organ residence times for the no voiding situation. Separate bladder residence-time calculations were performed for the cases of a 1- and a 2-h voiding interval. Using the source organ residence times as input, the program OLINDA/EXM (Stabin et al. in J Nucl Med. 46:1023-1027, 2005) was used to perform dosimetry calculations for the various body organs and for the whole body.ResultsFor the no voiding situation, the average whole-body radiation equivalent dose was 3.02 × 10−3mSv/MBq of injected [11C]FMZ. The average effective dose and effective dose equivalent was 7.57 × 10−3and 1.12 × 10−2mSv MBq−1, respectively. The organ receiving the highest equivalent dose was the urinary bladder wall with an average of 6.32 × 10−2mSv MBq−1.ConclusionOn average, the administration of less than 790 MBq (21 mCi) of [11C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit.