Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives
Epigenetics in hepatocellular carcinoma: An update and future therapy perspectives
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DOI：
10.3748/wjg.v20.i2.333
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发表时间：
2014-01-14
影响因子：
4.3
通讯作者：
So, Samuel
中科院分区：
文献类型：
--
作者：
Ma, Li;Chua, Mei-Sze;So, Samuel
肝细胞癌（HCC）是成人肝脏恶性肿瘤的主要形式，是一个全球性的健康问题。其预后差，促使最近的重大进展，其病因和发病机制的理解。维持可遗传基因表达变化和染色质组织的表观遗传机制的失调与多种癌症（包括HCC）的发展有关。本文就肝细胞癌的表观遗传学机制作一综述，重点介绍慢性B型肝炎病毒感染介导的肝细胞癌。该综述还讨论了血液和其他实体癌表观遗传疗法的令人鼓舞的结果和经验教训，并强调了类似疗法在HCC治疗中的未来潜力。(c)2014百世登出版集团有限公司有限公司All rights reserved.
Hepatocellular carcinoma (HCC), the predominant form of adult liver malignancies, is a global health concern. Its dismal prognosis has prompted recent significant advances in the understanding of its etiology and pathogenesis. The deregulation of epigenetic mechanisms, which maintain heritable gene expression changes and chromatin organization, is implicated in the development of multiple cancers, including HCC. This review summarizes the current knowledge of epigenetic mechanisms in the pathogenesis of HCC, with an emphasis on HCC mediated by chronic hepatitis B virus infection. This review also discusses the encouraging outcomes and lessons learnt from epigenetic therapies for hematological and other solid cancers, and highlights the future potential of similar therapies in the treatment of HCC. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.