Dichotomous physiological effects of nocturnal external nasal dilation in heavy snorers: The answer to a rhinologic controversy?
Dichotomous physiological effects of nocturnal external nasal dilation in heavy snorers: The answer to a rhinologic controversy?
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DOI：
10.2500/105065801781543745
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发表时间：
2001-03-01
期刊：
影响因子：
--
通讯作者：
Borgersen, AK
中科院分区：
文献类型：
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作者：
Djupesland, PG;Skatvedt, O;Borgersen, AK
本文旨在研究鼻外扩张对鼻气道尺寸、睡眠结构和打鼾的影响。18例重度打鼾者，无严重阻塞性睡眠呼吸暂停综合征（平均呼吸暂停低通气指数（AHI）9.3），报告夜间鼻塞，被纳入一项随机（对照）交叉研究，评价鼻外扩张的主观和客观效果（Breathe Right，3 M）。在一周的试验前nln-入组期间，也佩戴了有源扩张器。连续两个晚上进行多导睡眠描记术、打鼾记录和重复声学呼气末正压测量，一个晚上使用活性扩张器，一个晚上使用安慰剂条。在睡眠实验室中比较两个晚上时，导入期报告的与之前未使用扩张器的时期相比的显著主观改善（p < 0.01）仅在鼻通畅性方面保持（p < 0.05）。在晚上和第二天早上，与安慰剂相比，使用活性扩张剂的鼻尺寸显著增加（p < 0.001）。在习惯性打鼾者（AHI < 10）伴严重晨起阻塞（合并最小横截面积< 0.6 cm 2）的亚组（n = 6）中，外扩张显著改善了平均睡眠PaSO 2（92.4 -> 96.7）和PaSO 2 < 95%的睡眠百分比（49.9% -> 4.9%）。（p < 0.05）。在这个亚组中，（7.4 --> 5.4）有降低的趋势（p = 0.06），而在夜间鼻径较大的12人组中，AHI显著增加（p < 0.05）。打鼾的持续时间和强度保持不变，无论亚组。客观的有益效果仅限于夜间血氧饱和度和AHI在一个亚组的习惯性重度打鼾者确定的重复声学呼吸测量，其中外部扩张客观地减轻了显着的夜间鼻塞。这种Sinning可能提供了一个逻辑的解释相矛盾的结果，医疗，外科手术和机械扩张的鼻尺寸打鼾和睡眠障碍。
The purpose of this article was to study the impact of external dilation on nasal airway dimensions, sleep architecture , and snoring. Eighteen heavy snorers without severe obstructive sleep apnea syndrome (mean apnea-hypopnea index (AHI) 9.3) reporting nocturnal nasal obstruction were enrolled in a randomized (controlled) cross-over study, evaluating subjective and objective effects of external nasal dilation (Breathe Right, 3M). The active dilator was also worn during a one-week pretrial nln-in period. Polysomnography, recording of snoring sounds, and repeated acoustic rhinometry were performed on two consecutive nights, one with the active dilator and one with a placebo strip. The significant subjective improvement reported during the run-in period compared to the preceding period without dilator (p < 0.01), remained only for nasal patency (p < 0.05) when comparing the two nights in the sleep laboratory. The nasal dimensions increased significantly (p < 0.001) with the active dilator compared to placebo, both in the evening and the next morning. In a subgroup (n = 6) of habitual snorers (AHI < 10) with severe morning obstruction (combined minimal cross-sectional area < 0.6 cm(2)), external dilation significantly improved the mean sleep PaSO2 (92.4 --> 96.7) and the percentage of sleep with a PaSO2 < 95% (49.9% --> 4.9%).(p < 0.05). In this subgroup there was a trend toward reduction in (7.4 --> 5.4) (p = 0.06), whereas the AHI increased significantly in the group of 12 with larger nocturnal nasal dimensions (p < 0.05). Duration and intensity of snoring remained unchanged regardless of the subgrouping. Objective beneficial effects were restricted to nocturnal oxygen saturation and AHI in a subgroup of habitual heavy snorers identified by repeated acoustic rhinometry, in whom external dilation objectively relieved marked nocturnal nasal obstruction This Sinning may provide a logical explanation for the conflicting results of medical, surgical, and mechanical expansion of the nasal dimensions on snoring and sleep disturbances.