Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation
Biodegradable and Electroactive Regenerated Bacterial Cellulose/MXene (Ti3C2Tx) Composite Hydrogel as Wound Dressing for Accelerating Skin Wound Healing under Electrical Stimulation
复制标题
可生物降解和电活性再生细菌纤维素/MXene (Ti3C2TX) 复合水凝胶作为伤口敷料，可在电刺激下加速皮肤伤口愈合
DOI：
10.1002/adhm.202000872
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发表时间：
2020-08-31
影响因子：
10
通讯作者：
Yang, Guang
中科院分区：
文献类型：
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作者：
Mao, Lin;Hu, Sanming;Yang, Guang
传统的创面敷料主要参与被动愈合过程，很少通过刺激皮肤细胞行为参与主动创面愈合。已知电刺激(ES)可调节皮肤细胞行为。为此，首次开发了一系列基于再生细菌纤维素(RBC)和MXene(Ti3C2Tx)的多功能水凝胶，可以在体外ES下电调节细胞行为，促进皮肤创面的主动愈合。含有2wt%MXene(RBC/MXene-2%)的复合水凝胶具有最高的电导率和最好的生物相容性。同时，RBC/MXene-2%水凝胶具有良好的力学性能、良好的柔韧性、良好的生物降解性和高吸水性。利用大鼠全层缺损模型进行的体内研究表明，这种RBC/MXene水凝胶显示出比商业Tegaderm膜更好的治疗效果。更重要的是，体内外数据表明，与ES偶联的水凝胶与非ES对照组相比，可以显著增强NIH3T3细胞的增殖活性，加速伤口愈合过程。本研究表明，可生物降解且具有电活性的RBC/MXene水凝胶是一种很有吸引力的皮肤创面敷料，同时也为通过ES与水凝胶敷料的偶联促进创面修复提供了一种有效的协同治疗策略。
Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged in active wound healing by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate skin cell behaviors. Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) and MXene (Ti3C2Tx) are first developed that can electrically modulate cell behaviors for active skin wound healing under external ES. The composite hydrogel with 2 wt% MXene (rBC/MXene‐2%) exhibits the highest electrical conductivity and the best biocompatibility. Meanwhile, the rBC/MXene‐2% hydrogel presents desired mechanical properties, favorable flexibility, good biodegradability, and high water‐uptake capacity. An in vivo study using a rat full‐thickness defect model reveals that this rBC/MXene hydrogel exhibits a better therapeutic effect than the commercial Tegaderm film. More importantly, in vitro and in vivo data demonstrate that coupling with ES, the hydrogel can significantly enhance the proliferation activity of NIH3T3 cells and accelerate the wound healing process, as compared to non‐ES controls. This study suggests that the biodegradable and electroactive rBC/MXene hydrogel is an appealing candidate as a wound dressing for skin wound healing, while also providing an effective synergistic therapeutic strategy for accelerating wound repair process through coupling ES with the hydrogel dressing.