Olfactory experience modulated apoptosis in the developing olfactory bulb.
Olfactory experience modulated apoptosis in the developing olfactory bulb.
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作者：
J. Najbauer;M. Leon
早期感觉刺激在塑造发育中的嗅觉系统的结构和功能方面起着关键作用。在这里，我们提供了正常发育过程中幼鼠嗅球细胞凋亡的第一个直接证据，我们还证明单侧鼻孔阻塞导致的嗅觉剥夺会导致被剥夺嗅球的肾小球和颗粒细胞层的凋亡细胞死亡急剧增加。副嗅球显示出非常高的细胞凋亡基础水平，但闭塞的副球在这方面与对照副球没有差异。这些结果表明，细胞凋亡可能是嗅觉系统根据生命早期经历的感觉刺激来调整其细胞数量的重要机制，从而为发育中的嗅觉系统提供了一种可塑性。
Early sensory stimulation plays a key role in shaping the structure and function of the developing olfactory system. Here, we provide the first direct evidence for apoptotic cell death in the olfactory bulbs of rat pups during normal development and we also demonstrate that olfactory deprivation by unilateral naris occlusion causes a dramatic increase in apoptotic cell death in the glomerular and granule cell layers of the deprived bulb. The accessory olfactory bulbs displayed a remarkably high basal level of apoptosis but the occluded accessory bulb did not differ in that regard from the control accessory bulb. These results suggest that apoptosis may be an important mechanism by which the olfactory system can adjust its cell numbers in response in sensory stimuli experienced in early life, thereby underlying one form of plasticity in the developing olfactory system.