Use of carboxyhaemoglobin levels to predict the development of diseases associated with cigarette smoking.
Use of carboxyhaemoglobin levels to predict the development of diseases associated with cigarette smoking.
复制标题
使用碳氧血红蛋白水平来预测与吸烟相关的疾病的发展。
作者：
N. Wald;S. Howard;P. Smith;A. Bailey
吸烟者的碳氧血红蛋白 (COHb) 水平全天变化，因为他们受到烟草消费模式和 COHb 消除速度的影响。描述了一种方法，通过该方法，可以使用单次 COHb 测量值和最近的吸烟史来估计每支香烟产生的平均 COHb“提升”、吸烟引起的每日一氧化碳 (CO) 吸收总量以及全天的平均 COHb 水平。这三个烟草烟雾吸收指数是在不同日期对九名健康吸烟者进行估计的，每组三个估计值均来自单独的 COHb 测定。这些指数在同一个人内具有合理的重复性，并且人与人之间的差异具有统计学上的高度显着性（P小于0-001）。例如，对于每天吸 15 至 40 支烟的吸烟者，吸烟导致的每日平均 COHb 水平估计为 0-7% 至 9-3%。这些差异足够大，足以区分因吸入和吸收烟草烟雾而导致患缺血性心脏病等疾病的风险可能存在的差异。与单独的 COHb 水平相比，建议的指数对验血时间和每日吸烟模式的依赖性也较小。一支香烟的 COHb 增加量与 CO 产量的比率可能比吸烟者的自我评估更准确地反映吸入深度。此外，在所研究的九名受试者中，这两种吸入测量之间几乎没有相关性。
Carboxyhaemoglobin (COHb) levels in tobacco smokers vary throughout the day since they are affected by the pattern of tobacco consumption and the rate at which COHb is eliminated. A method is described whereby a single COHb measurement together with a recent smoking history may be used to estimate the average COHb "boost" produced by each cigarette, the total daily carbon monoxide (CO) uptake from smoking, and the mean COHb level throughout the day. These three indices of tobacco smoke absorption were estimated in nine healthy cigarette smokers on different days, each set of three estimations being derived from separate COHb determinations. The indices were reasonably reproducible within the same person, and the differences between people were statistically highly significant (P less than 0-001). For example, the estimates of mean daily COHb level resulting from smoking ranged from 0-7% to 9-3% in smokers who smoked 15 to 40 cigarettes a day. These differences are sufficiently large to distinguish possible differences in the risk of developing diseases such as ischaemic heart disease which may result from the inhalation and absorption of tobacco smoke. The suggested indices also depend less on the time of the blood test and on the daily pattern of smoking than a COHb level alone. The ratio of the COHb boost to the CO yield of a cigarrette may reflect depth of inhalation more accurately than a smoker's self-assessment. Moreover there was little correlation between these two measures of inhalation in the nine subjects studied.