Rodent models in neuroscience research: is it a rat race?
Rodent models in neuroscience research: is it a rat race?
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DOI：
10.1242/dmm.026120
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发表时间：
2016-10-01
影响因子：
4.3
通讯作者：
Youn J
中科院分区：
文献类型：
--
作者：
Ellenbroek B;Youn J
啮齿动物（特别是小家鼠和褐家鼠）多年来一直是生物医学研究中使用最广泛的模型。过去二十年发生了显着的变化，与大鼠相比，小鼠在生物医学科学中发挥着越来越重要的作用。这种转变主要是由更大的小鼠遗传工具箱的可用性引起的，特别是基于胚胎干细胞的基因破坏靶向技术。随着最近出现的改变大鼠基因组的工具，特别是基因组编辑技术，两种生物之间的技术差距正在缩小，在为特定的生物学问题选择正确的模型系统时，考虑大鼠和小鼠之间的生理、解剖、生化和药理学差异变得更加重要。这篇简短的评论和随附的海报的目的是强调一些最重要的差异，并讨论它们对人类疾病研究的影响，特别关注神经精神疾病。摘要：在这篇海报概览中，Ellenbroek 和 Youn 描述了大鼠和小鼠之间的重要差异，这些差异影响了它们作为脑部疾病模型生物的用途。
Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used models in biomedical research for many years. A notable shift has taken place over the last two decades, with mice taking a more and more prominent role in biomedical science compared to rats. This shift was primarily instigated by the availability of a much larger genetic toolbox for mice, particularly embryonic-stem-cell-based targeting technology for gene disruption. With the recent emergence of tools for altering the rat genome, notably genome-editing technologies, the technological gap between the two organisms is closing, and it is becoming more important to consider the physiological, anatomical, biochemical and pharmacological differences between rats and mice when choosing the right model system for a specific biological question. The aim of this short review and accompanying poster is to highlight some of the most important differences, and to discuss their impact on studies of human diseases, with a special focus on neuropsychiatric disorders. Summary: In this At a Glance poster review, Ellenbroek and Youn describe important differences between rats and mice that impact on their use as model organisms for brain disorders.