The course of asthma activity: A population study
The course of asthma activity: A population study
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DOI：
10.1016/j.jaci.2011.11.014
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发表时间：
2012-03-01
影响因子：
14.2
通讯作者：
To, Teresa
中科院分区：
文献类型：
--
作者：
Gershon, Andrea;Guan, Jun;To, Teresa
背景资料：与大多数倾向于随时间进展的慢性疾病不同，已知哮喘持续存在，可能消退，和/或存在缓解和复发的任何组合。因此，它的过程一直难以表征，其预后难以预测。目的：量化患有活动性疾病的哮喘个体的比例，以及其中经历哮喘活动性显著差异的比例;并确定与哮喘活动性相关的因素。1993年，使用全民健康管理数据库来识别所有生活在加拿大安大略的哮喘患者，并随访15年。结果：1993年613，394例哮喘患者中，504，851例（82.3%）在随后的几年中有活动性疾病。在完成随访的患者中，74.6%的患者在哮喘活动方面有2年或2年以上的差距。以前的哮喘索赔，老年人和年轻人的年龄，慢性阻塞性肺疾病的共同诊断与更大的哮喘activity.Conclusion：超过15年，大多数人与哮喘在加拿大安大略，有活跃的疾病，是由不活动的时期，当他们不需要医疗照顾，并可能在缓解穿插。这些分析提供了对哮喘活动的自然过程的深入了解，这可能有助于提高预测个体疾病过程的能力。（J Allergy Clin Immunol 2012; 129：679-86.）
Background: Unlike most chronic diseases, which tend to progress over time, asthma is known to persist, possibly resolve, and/or present with any combination of remissions and relapses. As a result, its course has been difficult to characterize and its prognosis difficult to predict.Objective: To quantify the proportion of individuals with asthma who have active disease and, of those, the proportion who experience significant gaps in their asthma activity; and to determine factors associated with asthma activity.Methods: Universal population health administrative databases were used to identify all individuals with asthma living in Ontario, Canada, in 1993 and follow them for 15 years. Active asthma was indicated by 1 or more physician claims for asthma.Results: Of 613,394 individuals with asthma in 1993, 504,851 (82.3%) had active disease in subsequent years. Of those who had complete follow-up, 74.6% experienced a gap of 2 or more years in their asthma activity. Previous asthma claims, older and younger age, and a codiagnosis of chronic obstructive pulmonary disease correlated with greater asthma activity.Conclusion: Over 15 years, most individuals with asthma in Ontario, Canada, had active disease that was interspersed by periods of inactivity when they did not require medical attention and were likely in remission. These analyses offer insight into the natural course of asthma activity that may help improve the ability to predict an individual's course of disease. (J Allergy Clin Immunol 2012; 129: 679-86.)