Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts.
Epithelial-to-mesenchymal transition transcription factors in cancer-associated fibroblasts.
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DOI：
10.1002/1878-0261.12080
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发表时间：
2017-07
影响因子：
6.6
通讯作者：
Baulida J
中科院分区：
文献类型：
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作者：
Baulida J
除了诱导上皮间质转录（EMT），Snail，ZEB和Twist家族（EMT-TF）的转录因子控制影响细胞干细胞和命运的全球可塑性计划。关于这些因子在成人肿瘤细胞中的再活化的文献非常广泛，因为它们使癌细胞具有可塑性并促进肿瘤起始和转移扩散。早期数据显示，EMT-TF也在成纤维细胞中表达，为这些细胞提供了额外的特性。在这里，我将回顾最近关于EMT-TF在癌症相关成纤维细胞（CAF）中表达的报道。新的模型表明，EMT-TF可以被设想为重要的转移和化疗耐药性促进分子，从而使实质和基质-肿瘤隔室中的协调可塑性方案成为可能。
Beyond inducing epithelial‐to‐mesenchymal transcription (EMT), transcriptional factors of the Snail, ZEB and Twist families (EMT‐TFs) control global plasticity programmes affecting cell stemness and fate. Literature addressing the reactivation of these factors in adult tumour cells is very extensive, as they enable cancer cell plasticity and fuel both tumour initiation and metastatic spread. Incipient data reveal that EMT‐TFs are also expressed in fibroblasts, providing these with additional properties. Here, I will review recent reports on the expression of EMT‐TFs in cancer‐associated fibroblasts (CAFs). The new model suggests that EMT‐TFs can be envisioned as essential metastasis and chemoresistance‐promoting molecules, thereby enabling coordinated plasticity programmes in parenchyma and stroma–tumour compartments.