Controlled trial of long term oral potassium supplements in patients with mild hypertension.
Controlled trial of long term oral potassium supplements in patients with mild hypertension.
复制标题
轻度高血压患者长期口服钾补充剂的对照试验。
作者：
Alfonso Siani;Pasquale Strazzullo;Litterio Russo;Sergio Guglielmi;L. Iacoviello;Aldo Ferrara;Mario Mancini
一项为期15周的随机双盲安慰剂对照试验对37名血压轻度升高、饮食中钠摄入量正常的患者进行了口服补钾(每天48 mmol)试验。经过两个月的试验和一周的基准期，患者被随机分配接受补钾(n=18)或安慰剂(n=19)。在治疗的第三周，主动治疗组的血压与安慰剂组相比显著降低，尽管在15周后降幅达到最大。补钾组大鼠尿钾排泄量显著增加，但血钠和血钾浓度及尿钠排泄量无明显变化。在一个由13名患者组成的小组中，他们又接受了9周的口服补钾治疗，治疗剂量是之前剂量的一半(每天24 mmoL)，在第二个研究阶段结束时，他们的血压仍然显著低于他们的基准值，但与安慰剂组相比没有下降。这些结果表明，在患有轻度高血压的患者中，适量的口服补钾与长期降压有关。
A 15 week randomised double blind placebo controlled trial of oral potassium supplements (48 mmol daily) was conducted in 37 patients who had mildly increased blood pressure and a normal dietary intake of sodium. After a two month run in and a one week baseline period the patients were randomly assigned to receive either potassium supplements (n = 18) or placebo (n = 19). By the third week of treatment blood pressure in the actively treated group had decreased significantly compared with that in the placebo group, though the decrease reached its maximum after 15 weeks. Urinary potassium excretion increased significantly in the group who received potassium supplements, but no significant changes were found in plasma sodium and potassium concentrations or in urinary sodium excretion. In a subgroup of 13 patients who underwent a further nine weeks of treatment with oral potassium supplements at half of the previous dose (24 mmol daily) their blood pressure, at the end of this second study period, was still significantly lower compared with their baseline value but not with that of the placebo group. These results show that moderate oral potassium supplements are associated with a long term reduction in blood pressure in patients who have mild hypertension.