CAFFEINE - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF ITS THERMOGENIC, METABOLIC, AND CARDIOVASCULAR EFFECTS IN HEALTHY-VOLUNTEERS
CAFFEINE - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF ITS THERMOGENIC, METABOLIC, AND CARDIOVASCULAR EFFECTS IN HEALTHY-VOLUNTEERS
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DOI：
10.1093/ajcn/51.5.759
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发表时间：
1990-05-01
影响因子：
7.1
通讯作者：
MADSEN, J
中科院分区：
文献类型：
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作者：
ASTRUP, A;TOUBRO, S;MADSEN, J
在人类中，咖啡因通过未知的机制刺激产热，并且其对体重的影响尚未被研究。在一项双盲研究中，对习惯性适度摄入咖啡因的健康受试者进行了双盲研究，研究了安慰剂和 100、200 和 400 毫克口服咖啡因对能量消耗、底物和激素血浆浓度、血压和心率的影响。咖啡因剂量依赖性地增加能量消耗，产热反应与血浆咖啡因（r = 0.52；p < 0.018）、血浆乳酸（r = 0.79；p < 0.000001）和血浆甘油三酯（r = 0.53；p < 0.02）的反应呈正相关。以生热反应为因变量的逐步回归分析排除了血浆咖啡因，并得出以下方程：热效应（千卡/3小时）=-0.00459×。心率+0.30315次。 (甘油三酯)+0.53114× （乳酸）+ 15.34（r = 0.86；p = 0.0001）。结果表明，乳酸和甘油三酯的产生以及血管平滑肌张力的增加可能是咖啡因生热作用的主要部分。
In humans caffeine stimulates thermogenesis by unknown mechanisms and its effect on body weight has not been studied. The effect of placebo and 100, 200, and 400 mg oral caffeine on energy expenditure, plasma concentrations of substrates and hormones, blood pressure, and heart rate was investigated in a double-blind study in healthy subjects who had a moderate habitual caffeine consumption. Caffeine increased energy expenditure dose dependently and the thermogenic response was positively correlated with the response in plasma caffeine (r = 0.52; p < 0.018), plasma lactate (r=0.79; p < 0.000001), and plasma triglyceride (r = 0.53; p < 0.02). Stepwise regression analysis with the thermogenic response as the dependent variable excluded plasma caffeine and yielded the following equation: thermic effect (kcal/3 h) = -0.00459 .times. heart rate + 0.30315 .times. (triglyceride) + 0.53114 .times. (lactate) + 15.34 (r = 0.86; p = 0.0001). The results suggest that lactate and triglyceride production and increased vascular smooth muscle tone may be responsible for the major part of the thermogenic effect of caffeine.