Novel autoantigens for diabetogenic CD4 T cells in autoimmune diabetes
Novel autoantigens for diabetogenic CD4 T cells in autoimmune diabetes
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DOI：
10.1007/s12026-012-8375-6
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发表时间：
2013-03-01
影响因子：
4.4
通讯作者：
Haskins, Kathryn
中科院分区：
文献类型：
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作者：
Delong, Thomas;Baker, Rocky L.;Haskins, Kathryn
自身反应性CD4 T细胞在1型糖尿病的发展中起着核心作用。糖尿病源性T细胞克隆的BDC组最初是从非肥胖糖尿病小鼠中分离出来的，并已被用于研究自身反应性CD4 T细胞和T细胞自身抗原在糖尿病发展中的作用。我们小组最近的研究已经为这个小组的克隆鉴定了两个新的靶抗原。本文综述了用于抗原鉴定的蛋白质组学策略，鉴定的抗原，以及翻译后修饰对自身抗原产生的潜在贡献。此外，我们比较了T细胞克隆的肽表位，并讨论了它们在研究T细胞自身抗原在疾病发病和调节中的作用方面的潜在应用。
Autoreactive CD4 T cells play a central role in the development of type 1 diabetes. The BDC panel of diabetogenic T cell clones was originally isolated from non-obese diabetic mice and has been used to study the role of autoreactive CD4 T cells and T cell autoantigens in the development of diabetes. Recent studies by our group have led to the identification of two new target antigens for clones of this panel. This review describes the proteomic strategy used for antigen identification, the antigens identified, and the potential contribution of post-translational modification to autoantigen generation. In addition, we compare peptide epitopes for the T cell clones and discuss their potential applications in investigating the role of T cell autoantigens in the pathogenesis and regulation of disease.