Ultrasound assisted ionic liquid dispersive liquid phase extraction of lovastatin and simvastatin: a new pretreatment procedure.
Ultrasound assisted ionic liquid dispersive liquid phase extraction of lovastatin and simvastatin: a new pretreatment procedure.
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DOI：
10.1002/jssc.200900337
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发表时间：
2009-09
影响因子：
3.1
通讯作者：
T. Mao;Bo Hao;Jin He;Weilin Li;Shengqing Li;Ziniu Yu
中科院分区：
文献类型：
--
作者：
T. Mao;Bo Hao;Jin He;Weilin Li;Shengqing Li;Ziniu Yu
建立了一种快速、新颖的样品前处理方法：超声辅助离子液体分散液萃取法测定水样中洛伐他汀和辛伐他汀的浓度。以IL([C(6)MIM][PF(6)])为萃取剂，对影响萃取率的因素如起始温度、IL用量、水样pH值、冷却时间、盐浓度等进行了优化。结合高效液相色谱-紫外检测器，洛伐他汀和辛伐他汀在1~100 ng/mL范围内呈良好的线性关系。洛伐他汀和辛伐他汀的检出限分别为0.17和0.29 ng/mL。方法精密度(RSD，n=9)分别为4.12%和4.52%。该方法已成功地用于3个实际水样中目标化合物的分析，洛伐他汀和辛伐他汀的加标回收率分别为90.0-102.2%和80.5-112.0%。这些结果表明，超声辅助离子液体分散液相萃取在环境样品前处理中具有良好的应用前景。
A fast and novel sample preparation procedure: ultrasound assisted ionic liquid (IL) dispersive liquid extraction for the concentration of lovastatin and simvastatin in aqueous samples was developed. An IL ([C(6)MIM][PF(6)]) was used as the extraction solvent, and the factors affecting the extraction efficiency such as initial temperature, the volume of IL, pH of water samples, cooling time, and salt concentration were optimized. In combination with HPLC-UV, both lovastatin and simvastatin exhibited a good linear range of 1-100 ng/mL. The limits of detection (LODs) of lovastatin and simvastatin were 0.17 and 0.29 ng/mL, respectively. Precisions of the proposed method (RSDs, n = 9) were 4.12 and 4.52%, respectively. This method has been successfully applied for the analysis of target compounds in three real water samples and good spiking recoveries were obtained in the range of 90.0-102.2% for lovastatin and 80.5-112.0% for simvastatin. These results indicated that ultrasound assisted IL dispersive liquid phase extraction would have good application prospect in the pretreatment of environmental samples.