Association Between the Decline in Muscle Health and the Decline in Bone Health in Older Individuals from the SarcoPhAge Cohort
Association Between the Decline in Muscle Health and the Decline in Bone Health in Older Individuals from the SarcoPhAge Cohort
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DOI：
10.1007/s00223-018-0503-4
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发表时间：
2019-03-01
影响因子：
4.2
通讯作者：
Bruyere, Olivier
中科院分区：
文献类型：
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作者：
Locquet, Medea;Beaudart, Charlotte;Bruyere, Olivier
骨骼健康和肌肉健康之间的纵向关系很少探索。我们的目的是探讨老年人1年以上的骨衰退和肌肉衰退之间的关系。我们使用了来自SarcoPhAge队列的数据，该队列旨在确定肌肉减少症的后果。通过这种方式，这项研究还强调了肌肉质量（通过双能吸收法），肌肉无力（通过握力）和/或身体表现（通过短期身体表现电池测试）的年度变化。每年还进行面积骨矿物质密度（aBMD）测量，以诊断骨质疏松症和骨微结构（通过骨小梁评分）。使用Edwards-Nunnally指数证明了1年骨和肌肉健康成分的临床相关下降。在232名数据完整的参与者中，（75.5 ± 5.4岁，57.8%的女性），我们观察到临床相关的骨骼肌质量指数（SMI）下降和aBMD下降之间的相关性。（调整后的OR=2.12 [1.14-2.51]（脊柱）、2.42 [1.10-5.34]（髋关节）和2.12 [1.04-5.81]（颈部）），以及SMI与骨骼微结构恶化之间的显著相关性（aOR=3.99 [2.07-7.70]）。临床相关的肌力下降仅与脊柱aBMD（aOR=2.93 [1.21-7.12]）和髋关节aBMD（aOR=3.42 [1.37-7.64]）降低相关。肌肉性能下降仅与骨微结构下降相关（aOR=2.52 [1.23-5.17]）。肌肉减少症患者并发骨质疏松症的风险约为正常人的5倍。观察到受损的肌肉和骨骼健康之间的动态关系，骨质疏松症和肌肉减少症的伴随发病率之间存在明显关联。
The longitudinal relationship between bone health and muscle health is scarcely explored. We aimed to explore the relationship between bone decline and muscle decline over 1year in older individuals. We used data from the SarcoPhAge cohort, which aims to identify the consequences of sarcopenia. In this way, this study also highlights the yearly changes in muscle mass (by dual-energy absorptiometry), muscle weakness (by grip strength), and/or physical performance (by the short physical performance battery test). Measurements of areal bone mineral density (aBMD), enabling the diagnosis of osteoporosis, and bone microarchitecture (by means of the trabecular bone score) were also performed each year. A 1-year clinically relevant decline in bone and muscle health components was evidenced using the Edwards-Nunnally index. Among the 232 participants with complete data (75.5 +/- 5.4years, 57.8% women), we observed an association between a clinically relevant decline in the skeletal muscle mass index (SMI) and a decrease in aBMD (adjusted OR=2.12 [1.14-2.51] for the spine, 2.42 [1.10-5.34] for the hip and 2.12 [1.04-5.81] for the neck), as well as a significant association between SMI and deterioration of the skeletal microarchitecture (aOR=3.99 [2.07-7.70]). A clinically relevant decline in muscle strength was associated with a decrease in spine aBMD (aOR=2.93 [1.21-7.12]) and hip aBMD (aOR=3.42 [1.37-7.64]) only. The decline in muscle performance was related to the decline in bone microarchitecture only (aOR=2.52 [1.23-5.17]). Individuals with incident sarcopenia had an approximately fivefold higher risk of concomitantly developing osteoporosis. A dynamic relationship between impaired muscle and bone health was observed, with an obvious association between the concomitant incidences of osteoporosis and sarcopenia.