Is an activator protein-2-like transcription factor involved in regulating gene expression during nitrogen limitation in fungi?
Is an activator protein-2-like transcription factor involved in regulating gene expression during nitrogen limitation in fungi?
复制标题
激活蛋白 2 样转录因子是否参与真菌氮限制期间基因表达的调节？
DOI：
10.1128/aem.59.7.2335-2338.1993
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发表时间：
1993
影响因子：
4.4
通讯作者：
Dhawale,SS
中科院分区：
文献类型：
--
作者：
Dhawale,SS
分析了所有已发表的黄孢原毛平革菌木质素过氧化物酶和锰过氧化物酶基因组克隆的上游序列。该分析揭示了15个木质素过氧化物酶基因中的11个中存在假定的激活蛋白-2（AP-2）识别序列。木质素过氧化物酶克隆GLG 6和锰过氧化物酶基因（mnp-1）在上游区域具有两个拷贝的推定AP-2序列。有趣的是，另一种白色腐烂真菌变色栓菌的木质素过氧化物酶基因VLG 4和粗糙脉孢菌的nit-2基因也含有推定的AP-2结合序列。由于所有这些基因都受到营养氮的调控，我推测AP-2样转录因子可能参与诱导真菌氮限制过程中的基因表达。
The upstream sequences of all published lignin peroxidase and manganese peroxidase genomic clones from Phanerochaete chrysosporium were analyzed. This analysis revealed the presence of putative activator protein-2 (AP-2) recognition sequences in 11 of 15 lignin peroxidase genes. The lignin peroxidase clone GLG6 and the manganese peroxidase gene (mnp-1) have two copies of putative AP-2 sequence in the upstream region. Interestingly, the lignin peroxidase gene VLG4 of another white rot fungus, Trametes versicolor, and the nit-2 gene of Neurospora crassa also contain putative AP-2-binding sequences. Since all of these genes are regulated by nutrient nitrogen, I hypothesize that an AP-2-like transcription factor may be involved in inducing gene expression during nitrogen limitation in fungi.