DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks
DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks
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DOI：
10.1093/bioinformatics/btq538
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发表时间：
2010-11-01
期刊：
影响因子：
5.8
通讯作者：
Furlong, Laura I.
中科院分区：
文献类型：
--
作者：
Bauer-Mehren, Anna;Rautschka, Michael;Furlong, Laura I.
DisGeNET是Cytoscape的一个插件，用于查询和分析人类基因-疾病网络。DisGeNET允许用户友好地访问我们通过整合来自多个公共来源的数据开发的新基因疾病数据库。DisGeNET允许仅限于（i）原始数据源，（ii）关联类型，（iii）疾病类别或（iv）特定基因/疾病的查询。它以二分图的形式表示基因与疾病的关联，并提供以基因为中心和以疾病为中心的数据视图。它通过各种内置功能帮助用户解释和探索人类疾病的遗传基础。此外，DisGeNET允许根据标准疾病分类对节点（基因/疾病）进行多色处理，以便于可视化。
DisGeNET is a plugin for Cytoscape to query and analyze human gene-disease networks. DisGeNET allows user-friendly access to a new gene-disease database that we have developed by integrating data from several public sources. DisGeNET permits queries restricted to (i) the original data source, (ii) the association type, (iii) the disease class or (iv) specific gene(s)/disease(s). It represents gene-disease associations in terms of bipartite graphs and provides gene centric and disease centric views of the data. It assists the user in the interpretation and exploration of the genetic basis of human diseases by a variety of built-in functions. Moreover, DisGeNET permits multicolouring of nodes (genes/diseases) according to standard disease classification for expedient visualization.