Ultrahigh-speed swept-source OCT angiography in exudative AMD.
Ultrahigh-speed swept-source OCT angiography in exudative AMD.
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DOI：
10.3928/23258160-20141118-03
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
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作者：
Moult E;Choi W;Waheed NK;Adhi M;Lee B;Lu CD;Jayaraman V;Potsaid B;Rosenfeld PJ;Duker JS;Fujimoto JG
探讨超高速扫频光源光学相干断层扫描血管造影（OCTA）显示渗出性年龄相关性黄斑变性（AMD）患者视网膜和脉络膜血管变化的潜力。观察性、前瞻性横断面研究。使用超高速扫描源原型对32名健康对照者的63只眼睛和15名渗出性AMD患者的19只眼睛进行视网膜和脉络膜毛细血管的OCTA。主要观察指标：两组视网膜和脉络膜毛细血管的定性比较。19只渗出型AMD患者中有16只眼脉络膜新生血管（CNV）清晰可见，位于严重脉络膜毛细血管改变区域上方。其中14只眼的CNV病变被脉络膜毛细血管改变所包围。OCTA可以提供对CNV患者的视网膜和脉络膜毛细血管微血管的无创监测，这可能有助于诊断和监测。
To investigate the potential of ultrahigh-speed swept-source optical coherence tomography angiography (OCTA) to visualize retinal and choroidal vascular changes in patients with exudative age-related macular degeneration (AMD). Observational, prospective cross-sectional study. An ultrahigh-speed swept-source prototype was used to perform OCTA of the retinal and choriocapillaris microvasculature in 63 eyes of 32 healthy controls and 19 eyes of 15 patients with exudative AMD. Main outcome measure: qualitative comparison of the retinal and choriocapillaris microvasculature in the two groups. Choroidal neovascularization (CNV) was clearly visualized in 16 of the 19 eyes with exudative AMD, located above regions of severe choriocapillaris alteration. In 14 of these eyes, the CNV lesions were surrounded by regions of choriocapillaris alteration. OCTA may offer noninvasive monitoring of the retinal and choriocapillaris microvasculature in patients with CNV, which may assist in diagnosis and monitoring.