Sympatho-adrenal involvement in methamphetamine-induced hyperthermia through skeletal muscle hypermetabolism
Sympatho-adrenal involvement in methamphetamine-induced hyperthermia through skeletal muscle hypermetabolism
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DOI：
10.1016/s0014-2999(98)00758-4
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发表时间：
1998-12-18
影响因子：
5
通讯作者：
Morimoto, A
中科院分区：
文献类型：
--
作者：
Makisumi, T;Yoshida, K;Morimoto, A
我们利用生物遥测系统研究了交感 - 肾上腺轴在甲基苯丙胺诱导的体温过高中的作用。对自由活动的大鼠腹腔注射甲基苯丙胺（1毫克/千克）会诱导体温过高，在此之前耗氧量会增加。用6 - 羟基多巴胺（50毫克/千克，腹腔注射）进行化学性交感神经切除术可完全阻断甲基苯丙胺的致热作用。肾上腺切除术，但不是肾上腺髓质切除术，可阻止体温过高。在肾上腺切除的大鼠中，地塞米松补充（0.5毫克/千克，皮下注射）可恢复甲基苯丙胺诱导的体温过高。此外，丹曲林（1或2毫克/千克，静脉注射）可阻断骨骼肌肌浆网中钙离子的释放，减轻体温过高。这些结果表明，甲基苯丙胺刺激交感神经末梢释放去甲肾上腺素，然后在糖皮质激素的允许作用下增强骨骼肌的产热作用。（C）1998年爱思唯尔科学出版社。版权所有。
We investigated the involvement of the sympatho-adrenal axis in the hyperthermia induced by methamphetamine by using a biotelemetric system. The intraperitoneal injection of methamphetamine (1 mg/kg) induced hyperthermia preceded by an increase in oxygen consumption in freely moving rats. The hyperthermic effect of methamphetamine was completely blocked by chemical sympathectomy with 6-hydroxydopamine (50 mg/kg, i.p.). Adrenalectomy, but not adrenal demedullation, prevented the hyperthermia. In adrenalectomized rats, dexamethasone supplementation (0.5 mg/kg, s.c.) restored the methamphetamine-induced hyperthermia. Furthermore, dantrolene (1 or 2 mg/kg, i.v.), which blocks Ca2+ release from the sarcoplasmic reticulum in skeletal muscle, attenuated the hyperthermia. These results suggest that methamphetamine stimulates norepinephrine release from sympathetic nerve terminals, which then enhances thermogenesis in skeletal muscle under the permissive action of glucocorticoids. (C) 1998 Elsevier Science B.V. All rights reserved.