Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?
Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?
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DOI：
10.1016/j.fertnstert.2007.07.1292
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发表时间：
2008-09-01
影响因子：
6.7
通讯作者：
Bonde, Jens Peter
中科院分区：
文献类型：
--
作者：
Aggerholm, Anette S.;Thulstrup, Ane Marie;Bonde, Jens Peter
目的：评估超重和肥胖是否与血清性激素浓度和精液质量的变化有关。设计：横断面研究。设置：来自丹麦一所大学医院的五项先前基于人群的精液质量环境研究的数据合并到一个数据库中。患者：总共有2，139名男性向数据库提供数据。干预措施：收集精液和血液样本的数据以及生活方式和生殖因素的信息，包括体重指数（BMI）。主要结果测量：精液质量（体积、浓度、精子总数和活力）和血清性激素浓度。结果（S）：与正常体重的男性相比，肥胖男性的T和B血清浓度低25%-32%，而肥胖男性的E浓度高6%。超重男性体重指数在25.1-30.0 kg/m2之间的男性，其调整后的精子浓度和精子总数略低于体重指数正常的男性（20.0-25.0 kg/m2），但在肥胖男性中未观察到精子数减少。这些结果证实了早期的发现，即超重和肥胖的男性血清中的性激素水平明显改变，而精液质量下降，如果有的话，是边缘性的，低于这项大型研究的检测限。
Objective: To evaluate whether overweight and obesity are related to changes in serum sex hormone concentrations and semen quality.Design: Cross-sectional study.Setting: Data from five previous population-based environmental studies of semen quality were combined into one database at a university hospital in Denmark.Patient(s): In total, 2,139 men provided data to the database.Intervention(s): Data on semen and blood samples and information on lifestyle and reproductive factors, including body mass index (BMI), were collected.Main Outcome Measure(s): Semen quality (volume, concentration, total sperm count, and motility) and serum concentration of sex hormones. Result(S): The T and inhibin B serum concentrations were 25%-32% lower in obese men in comparison with normal-weight men, whereas the E, concentration was 6% higher in obese men. Overweight men (BMI, 25.1-30.0 kg/m(2)) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0-25.0 kg/m(2)), but no reduction in sperm count was observed among the obese men.Conclusion(s): These results corroborate earlier findings that overweight and obese men have a markedly changed sex hormone profile in serum, whereas reduction of semen quality, if any, was marginal and below the detection limit of this large study.