Circulating triglycerides and bile acids are reduced by a soluble wheat arabinoxylan via modulation of bile concentration and lipid digestion rates in a pig model
Circulating triglycerides and bile acids are reduced by a soluble wheat arabinoxylan via modulation of bile concentration and lipid digestion rates in a pig model
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DOI：
10.1002/mnfr.201500686
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发表时间：
2016-03-01
影响因子：
5.2
通讯作者：
Gidley, Michael J.
中科院分区：
文献类型：
--
作者：
Gunness, Purnima;Williams, Barbara A.;Gidley, Michael J.
范围：可溶性膳食纤维已被证明具有降脂特性。然而，它们的作用机制仍不清楚。本研究调查了将富含可溶性小麦阿拉伯木聚糖的部分（AXRF）喂给用作人类模型的猪如何降低血液甘油三酯。方法和结果：在实验饮食4周后，收集来自颈静脉（JV）和肝门静脉（HPV）的血液、来自胆囊的胆汁以及来自小肠（SI）和盲肠四个部位的消化物样本。结果表明，AXRF 显着降低 HPV (p < 0.01)、JV (p < 0.01)、胆汁 (p < 0.05) 和 SI (p < 0.05) 中总胆汁酸 (BA) 的浓度，但对回肠 BA 排泄通量没有影响。此外，AXRF 还降低了血液甘油三酯 (TAG) 水平 (p < 0.01)，但对 LDL-、HDL- 或总胆固醇水平没有显着影响。较低的血浆 TAG 浓度与 AXRF 减少/延迟的 TAG 消化和吸收一致（总脂肪酸和 MUFA p < 0.01；不饱和脂肪酸 p < 0.05）。结论：结果表明 AXRF 降低了循环 BA 水平，从而减慢了 TAG 的消化和游离脂肪酸的吸收，从而减少了血液 TAG。阿拉伯木聚糖减少循环胆汁酸导致脂质消化和吸收减少。
Scope: Soluble dietary fibres have shown to have lipid reducing properties. However, their mechanisms of action are still unclear. The present study investigated how a soluble wheat arabinoxylan-rich fraction (AXRF) fed to pigs used as a human model reduced blood triglycerides.Methods and results: After 4 weeks on the experimental diets, blood from the jugular (JV) and hepatic portal (HPV) veins, bile from the gall bladder, and digesta samples from four sites of the small intestine (SI) and cecum were collected. The results showed that the AXRF significantly decreased the concentrations of total bile acid (BA) in the HPV (p < 0.01), JV (p < 0.01), bile (p < 0.05) and SI (p < 0.05), but with no effect on ileal BAs excretion flux. Furthermore, blood triglyceride (TAG) levels were also lower with AXRF (p < 0.01) but with no significant effects on LDL-, HDL-or total cholesterol levels. The lower plasma TAG concentration was consistent with the reduced/delayed digestion and absorption of TAG with the AXRF (total fatty acid and MUFA p < 0.01; unsaturated fatty acid p < 0.05).Conclusion: The results suggest that AXRF reduced the levels of circulating BAs which slowed down the digestion of TAG and absorption of free fatty acids, with consequent reduction in blood TAG. Reduction in circulating bile acids by arabinoxylan causes reduction in lipids digestion and absorption.