Saturated Fat Intake Is Associated with Lung Function in Individuals with Airflow Obstruction: Results from NHANES 2007-2012
Saturated Fat Intake Is Associated with Lung Function in Individuals with Airflow Obstruction: Results from NHANES 2007-2012
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DOI：
10.3390/nu11020317
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发表时间：
2019-02-01
期刊：
影响因子：
5.9
通讯作者：
Hanson, Corrine
中科院分区：
文献类型：
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作者：
Cornell, Kasey;Alam, Morshed;Hanson, Corrine
营养状况是慢性阻塞性肺疾病（COPD）公认的预后指标；然而，我们对肺功能和饱和脂肪摄入之间的关系知之甚少。我们使用横断面全国健康与营养调查（NHANES）的数据来评估美国普通成年人中饱和脂肪酸（SFA）摄入量与肺功能之间的关系。纳入NHANES（2007-2012）中支气管扩张剂前肺活量测定和膳食SFA摄入量的成年人。主要终点是肺功能，包括一秒钟用力呼气量（FEV1）、FEV1、用力肺活量（FVC）、FEV1/FVC比值、预测FEV1百分比和预测FVC百分比。在校正混杂因素后，使用普通人群以及肺量测定定义的气流阻塞患者的多变量回归模型来评估肺功能测量与膳食SFA摄入量之间的关系。本研究纳入了11,180名符合条件的参与者。单因素分析显示，SFA总摄入量与肺功能结局之间存在统计学上显著的正相关；然而，调整协变量后，这些关系减弱。对肺活量测定的气流阻塞（FEV1/FVC < 0.7）患者的二次分析显示，较低的SFA摄入量与FEV1（= -126.4，四分位1 vs四分位4 p = 0.04）和FVC（= -165.8）降低相关。四分位数1与四分位数4的p = 0.01)，百分比预测FVC（= -3.3）。四分位数1对四分位数4的P = 0.04)，校正相关混杂因素后。FEV1/FVC比率和预测FEV1百分比未观察到关联。食物来源和脂肪酸链长度等特征可能会影响饱和脂肪酸摄入量与健康结果之间的关联。
Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007-2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV1), FEV1, forced vital capacity (FVC), FEV1/FVC ratio, percent predicted FEV1 and percent predicted FVC. Multivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV1/FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV1 ( = -126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC ( = -165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC ( = -3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV1/FVC ratio and percent predicted FEV1. It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.