Ethnic Differences in Aortic Pulse Wave Velocity Occur in the Descending Aorta and May Be Related to Vitamin D
Ethnic Differences in Aortic Pulse Wave Velocity Occur in the Descending Aorta and May Be Related to Vitamin D
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DOI：
10.1161/hypertensionaha.111.174425
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发表时间：
2011-08-01
期刊：
影响因子：
8.3
通讯作者：
Cruickshank, J. Kennedy
中科院分区：
文献类型：
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作者：
Rezai, Mohammad-Reza;Wallace, A. Michael;Cruickshank, J. Kennedy
我们研究了主动脉脉搏波速度（aPWV），一个独立于血压的心血管事件的预测因子，在一个多种族的英国男性样本中，研究血液中维生素D和醛固酮水平在总的和局部的主动脉僵硬度中的作用。在198名男性中，通过动脉造影设备（aPWV（AG））无创地估计总aPWV，其长度测量通过磁共振校准。通过磁共振测量子样本（n = 47）主动脉弓和降主动脉上的PWV。南亚人的平均（SE）aPWV（AG）（n = 68;年龄55 +/- 10岁），已知冠心病风险高于其他组，为0.5 m/s（0.2米/秒）高于非洲加勒比地区（n = 67; 55 +/- 10岁），冠心病风险最低，欧洲人（n = 63; 57 +/- 8岁），校正年龄、收缩压和糖尿病（P = 0.01）。通过磁共振，南亚人降主动脉上的PWV分别比非洲加勒比人和欧洲人高0.7 m/s（0.3 m/s）和0.8 m/s（0.3 m/s）;主动脉弓上的PWV没有差异。南亚人和非洲加勒比人的平均（SE）25（OH）D比欧洲人低21 nmol/L（3 nmol/L）和14 nmol/L（3 nmol/L）（P
We studied aortic pulse wave velocity (aPWV), a predictor of cardiovascular events independent of blood pressure, in a multiethnic sample of British men, to investigate the roles for blood levels of vitamin D and aldosterone in total and regional aortic stiffness. Total aPWV was estimated noninvasively by the Arteriograph device (aPWV(AG)) in 198 men, with its length measure calibrated by magnetic resonance. PWVs over the aortic arch and descending aorta were measured by magnetic resonance in a subsample (n = 47). Mean (SE) aPWV(AG) in South Asians (n = 68; age 55 +/- 10 years), at known higher coronary disease risk than other groups, was 0.5 m/s (0.2 m/s) higher than in African Caribbeans (n = 67; 55 +/- 10 years), at lowest coronary disease risk here, and Europeans (n = 63; 57 +/- 8 years), adjusted for age, systolic blood pressure, and diabetes mellitus (P = 0.01). By magnetic resonance, PWV over the descending aorta in South Asians was 0.7 m/s (0.3 m/s) and 0.8 m/s (0.3 m/s) higher than in African Caribbeans and Europeans, respectively; PWV over the aortic arch was not different. South Asians and African Caribbeans had 21 nmol/L (3 nmol/L) and 14 nmol/L (3 nmol/L) lower mean (SE) 25(OH)D than Europeans (P