Reversibility of Neuronal Function of Hippocampal Slice during Deprivation of Oxygen and/or Glucose
Reversibility of Neuronal Function of Hippocampal Slice during Deprivation of Oxygen and/or Glucose
复制标题
缺氧和/或葡萄糖期间海马切片神经元功能的可逆性
DOI：
10.1007/978-1-4684-5562-5_22
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Y. Okada
中科院分区：
文献类型：
--
作者：
Y. Okada
在脑缺氧和缺血的研究中，主要的课题是缺血发作时神经元功能的可逆性。众所周知，缺氧或缺血会对脑功能和脑代谢造成严重损害，根据临床文献，正常情况下8-10分钟的脑完全缺血足以导致脑功能的不可逆丧失1。然而，在实验研究者中，关于神经元组织缺氧或缺血后神经元损伤可逆性的临界时间仍存在争议2。
In the study of brain anoxia and ischemia, the main topic has been the reversibility of the neuronal function during ischemic episode. It is well known that anoxia or ischemia cause critical damage to the brain function as well as brain metabolism, and according to the clinical literature 8–10 min of complete ischemia of normothermic brain is enough to cause irreversible loss of brain function1. Among experimental investigators, however, there is still controversy regarding the critical time for the reversibility of neuronal damage after anoxia or ischemia of neuronal tissue2.