Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study
Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study
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DOI：
10.3945/ajcn.114.101857
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发表时间：
2015-05-01
影响因子：
7.1
通讯作者：
Mozaffarian, Dariush
中科院分区：
文献类型：
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作者：
Lemaitre, Rozenn N.;Fretts, Amanda M.;Mozaffarian, Dariush
背景：循环饱和脂肪酸(SFA)是影响糖尿病发病机制的饮食和代谢的综合生物标志物。在流行病学研究中，循环棕榈酸水平(16：0)与糖尿病相关；然而，含有20个或更多碳的超长链脂肪酸(VLSFA)在生物活性上不同于棕榈酸，并且对循环VLSFA与糖尿病的相关性知之甚少。目的：通过使用心血管健康研究的数据，我们检查了基线测量的血浆磷脂VLSFA水平与随后发生的糖尿病的相关性。设计：研究基线(1992-1993年)时平均年龄为75岁的3179名老年人接受了跟踪调查。我们使用多重比例风险回归分析了花生四烯酸(20：0)、山毛桃酸(22：0)和甘油酸(24：0)与糖尿病的关系。结果：每种VLSFA的基线水平都与较低的甘油三酯水平和较低的循环棕榈酸水平有关。在随访期间，我们确定了284例糖尿病病例。与最低四分位数相比，脂肪酸分布中最高四分位数中的花生四分位酸水平与糖尿病风险降低47%相关(95%CI：23%，63%；P-趋势：
Background: Circulating saturated fatty acids (SFAs) are integrated biomarkers of diet and metabolism that may influence the pathogenesis of diabetes. In epidemiologic studies, circulating levels of palmitic acid (16:0) are associated with diabetes; however, very-long-chain SFAs (VLSFAs), with 20 or more carbons, differ from palmitic acid in their biological activities, and little is known of the association of circulating VLSFA with diabetes.Objective: By using data from the Cardiovascular Health Study, we examined the associations of plasma phospholipid VLSFA levels measured at baseline with subsequent incident diabetes.Design: A total of 3179 older adults, with a mean age of 75 y at study baseline (1992-1993), were followed through 2011. We used multiple proportional hazards regression to examine the associations of arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) with diabetes.Results: Baseline levels of each VLSFA were cross-sectionally associated with lower triglyceride levels and lower circulating palmitic acid. We identified 284 incident diabetes cases during follow-up. Compared with the lowest quartile, levels of arachidic acid in the highest quartile of the fatty acid distribution were associated with a 47% lower risk of diabetes (95% CI: 23%, 63%; P-trend: