Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients
Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients
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DOI：
10.1016/s0306-4530(03)00054-4
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发表时间：
2004-05-01
影响因子：
3.7
通讯作者：
Goodey, E
中科院分区：
文献类型：
--
作者：
Carlson, LE;Speca, M;Goodey, E
目的：本研究调查了早期乳腺癌和前列腺癌患者的正念减压冥想计划与生活质量、情绪状态、应激症状以及皮质醇、硫酸脱氢表雄酮（DHEAS）和褪黑激素水平之间的关系。59名乳腺癌患者和10名前列腺癌患者参加了为期8周的正念减压（MBSR）该计划包括放松，冥想，温和的瑜伽和日常家庭练习。人口统计学和健康行为变量，生活质量，情绪，压力，和唾液皮质醇的激素措施（评估三次/天），血浆DHEAS，和唾液褪黑激素进行了评估前和后intervention.Results：58和42例患者进行了评估前和干预后，分别。在整体生活质量、压力症状和睡眠质量方面都有显着改善，但这些改善与项目出勤率或家庭练习时间没有显着相关性。情绪障碍没有明显改善。生活质量的改善与下午皮质醇水平的下降有关，但与早晨或晚上的水平无关。压力症状或情绪的变化与激素水平的变化无关。大约40%的样本在干预前后都表现出异常的皮质醇分泌模式，但在该组中，模式从“倒V形”模式转向更多的“V形”分泌模式。DHEAS或褪黑激素没有整体变化，但DHEAS模式的非显着变化是一致的健康配置文件为男性和女性.Conclusions：正念减压疗法计划招生与乳腺癌和前列腺癌患者的生活质量提高和压力症状减少，并导致下丘脑-垂体-肾上腺（HPA）轴功能可能有益的变化。这些试点数据代表了MBSR项目参与和激素水平之间关系的初步调查，强调了在这一领域进行更好控制研究的必要性。(C)2003 Elsevier Ltd.保留所有权利。
Objectives: This study investigated the relationships between a mindfulness-based stress reduction meditation program for early stage breast and prostate cancer patients and quality of life, mood states, stress symptoms, and levels of cortisol, dehydroepiandrosterone-sulfate (DHEAS) and melatonin.Methods: Fifty-nine patients with breast cancer and 10 with prostate cancer enrolled in an eight-week Mindfulness-Based Stress Reduction (MBSR) program that incorporated relaxation, meditation, gentle yoga, and daily home practice. Demographic and health behavior variables, quality of life, mood, stress, and the hormone measures of salivary cortisol (assessed three times/day), plasma DHEAS, and salivary melatonin were assessed pre- and post-intervention.Results: Fifty-eight and 42 patients were assessed pre- and post-intervention, respectively. Significant improvements were seen in overall quality of life, symptoms of stress, and sleep quality, but these improvements were not significantly correlated with the degree of program attendance or minutes of home practice. No significant improvements were seen in mood disturbance. Improvements in quality of life were associated with decreases in afternoon cortisol levels, but not with morning or evening levels. Changes in stress symptoms or mood were not related to changes in hormone levels. Approximately 40% of the sample demonstrated abnormal cortisol secretion patterns both pre- and post-intervention, but within that group patterns shifted from "inverted-V-shaped" patterns towards more "V-shaped" patterns of secretion. No overall changes in DHEAS or melatonin were found, but nonsignificant shifts in DHEAS patterns were consistent with healthier profiles for both men and women.Conclusions: MBSR program enrollment was associated with enhanced quality of life and decreased stress symptoms in breast and prostate cancer patients, and resulted in possibly beneficial changes in hypothalamic-pituitary-adrenal (HPA) axis functioning. These pilot data represent a preliminary investigation of the relationships between MBSR program participation and hormone levels, highlighting the need for better-controlled studies in this area. (C) 2003 Elsevier Ltd. All rights reserved.