Range and Frequency of Congenital Malformations Among Children With Cleft Lip and/or Palate
Range and Frequency of Congenital Malformations Among Children With Cleft Lip and/or Palate
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DOI：
10.1177/10556656221089160
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发表时间：
2022-04-05
影响因子：
1.1
通讯作者：
Russell, C. J. H.
中科院分区：
文献类型：
--
作者：
Fitzsimons, K. J.;Hamilton, M. J.;Russell, C. J. H.
目的评估额外的先天性畸形的范围和频率，确定活产的儿童与CL/P。设计分析的患者水平的数据，从一个国家注册的裂产与国家行政数据的入院。英国国家卫生服务局。2000年至2012年出生的儿童在英国NHS医院接受唇腭裂护理。结果测量根据唇腭裂类型，有ICD-10编码的其他先天性畸形儿童的比例。结果共纳入9403名儿童。其中2114例（22.5%）为CL +/- A，4509例（48.0%）为CP，1896例（20.2%）为UCLP，884例（9.4%）为BCLP。共有3653名（38.8%）儿童在其入院记录中记录了其他先天性畸形。其他先天性畸形的患病率在CP儿童中最高（53.0%），其次是BCLP（33.5%），UCLP（26.3%），然后是CL +/- A（22.2%）（P <0.001）。在患有UCLP的儿童中，右侧唇腭裂的儿童比左侧唇腭裂的儿童更可能有其他畸形（31.6%比23.0%，P <0.001）。骨骼系统和循环系统畸形最常见，分别占纳入儿童的10.5%和10.2%。共有16.8%的儿童有额外的先天性畸形，影响2个或更多的结构系统。结论先天性畸形在先天性唇腭裂患儿中很常见，超过一半的唇腭裂患儿会受到影响。鉴于某些结构畸形的频率，临床医生应该考虑对这些儿童进行标准化筛查。建议与儿科和遗传服务部门建立良好的联系。
Objective To assess the range and frequency of additional congenital malformations identified among children born alive with CL/P. Design Analysis of patient-level data from a national registry of cleft births linked to national administrative data of hospital admissions. Setting National Health Service, England. Patients Children born between 2000 and 2012 receiving cleft care in English NHS hospitals. Outcome Measures The proportion of children with ICD-10 codes for additional congenital malformations, according to cleft type. Results The study included 9403 children. Of these 2114 (22.5%) had CL +/- A, 4509 (48.0%) had CP, 1896 (20.2%) had UCLP, and 884 (9.4%) had BCLP. A total of 3653 (38.8%) children had additional congenital malformations documented in their hospital admission records. The prevalence of additional congenital malformations was greatest among children with CP (53.0%), followed by those with BCLP (33.5%), UCLP (26.3%), and then CL +/- A (22.2%) (P < .001). Among those with UCLP, children with right-sided clefts were more likely to have additional malformations than those with left-sided clefts (31.6% vs 23.0%, P < .001). Malformations of the skeletal system and circulatory system were most common, affecting 10.5% and 10.2% of the included children, respectively. A total of 16.8% of children had additional congenital malformations affecting 2 or more structural systems. Conclusions Congenital malformations are common among children born alive with a cleft, affecting over half of some cleft subgroups. Given the frequency of certain structural malformations, clinicians should consider standardized screening for these children. Establishing good links with pediatric and genetic services is recommended.