Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts.
Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts.
复制标题
8-氨基鸟苷抑制嘌呤核苷磷酸化酶：对 T 淋巴细胞的选择性毒性。
DOI：
10.1126/science.6795718
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Kelley,WN
中科院分区：
文献类型：
--
作者：
Kazmers,IS;Mitchell,BS;Dadonna,PE;Wotring,LL;Townsend,LB;Kelley,WN
鸟苷类似物8-氨基鸟苷是嘌呤降解酶嘌呤核苷磷酸化酶的有效抑制剂，无论是在体外还是在完整的淋巴细胞中。在人淋巴母细胞组织培养系统中，8-氨基鸟苷与低浓度的2′-脱氧鸟苷组合对T细胞而不是B细胞产生毒性。选择性T细胞毒性与处理的T淋巴母细胞中脱氧鸟苷三磷酸的积累增加相关。
The guanosine analog 8-aminoguanosine is an effective inhibitor of the purine degradative enzyme purine nucleoside phosphorylase, both in vitro and in intact lymphoid cells. In a human lymphoblast tissue culture system, 8-aminoguanosine, in combination with low concentrations of 2′-deoxyguanosine, causes toxicity toward T cells but not B cells. The selective T cell toxicity correlates with increased accumulation of deoxyguanosine triphosphate in the treated T lymphoblasts.