The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.
The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.
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DOI：
10.1002/ajh.25008
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发表时间：
2018-03
影响因子：
12.8
通讯作者：
Ravid K
中科院分区：
文献类型：
--
作者：
Leiva O;Leon C;Kah Ng S;Mangin P;Gachet C;Ravid K
细胞外基质 (ECM) 是不断重塑的关键非细胞结构，可提供组织内聚力和刚性。基质沉积、降解和交联之间的平衡失调会导致纤维化。骨髓纤维化 (BMF) 与多种严重影响血细胞生成的恶性和非恶性病理有关。 BMF 是由胶原纤维异常沉积和骨髓内赖氨酰氧化酶介导的 ECM 交联增强引起的，从而增加了骨髓硬度。骨髓硬度最近被认为是血细胞发育的重要调节因子，特别是通过改变造血或间充质干细胞的命运和分化过程。本综述调查了 ECM 的不同成分及其对干细胞发育的影响，重点关注 ECM 成分和硬度对健康和疾病中巨核细胞谱系的影响。巨核细胞的成熟及其后代血小板的生物发生被认为是通过许多机械传感器（包括整合素和机械敏感离子通道）对环境机械力做出反应，本文综述。
The extracellular matrix (ECM) is a key acellular structure in constant remodeling to provide tissue cohesion and rigidity. Deregulation of the balance between matrix deposition, degradation and crosslinking results in fibrosis. Bone marrow fibrosis (BMF) is associated with several malignant and nonmalignant pathologies severely affecting blood cell production. BMF results from abnormal deposition of collagen fibers and enhanced lysyl oxidase-mediated ECM crosslinking within the marrow, thereby increasing marrow stiffness. Bone marrow stiffness has been recently recognized as an important regulator of blood cell development, notably by modifying the fate and differentiation process of hematopoietic or mesenchymal stem cells. This review surveys the different components of the ECM and their influence on stem cell development, with a focus on the impact of the ECM composition and stiffness on the megakaryocytic lineage in health and disease. Megakaryocyte maturation and the biogenesis of their progeny, the platelets, are thought to respond to environmental mechanical forces through a number of mechanosensors, including integrins and mechanosensitive ion channels, reviewed here.
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影响因子：
20.3
作者：
Beham-Schmid, C;Apfelbeck, U;Linkesch, W
通讯作者：
Linkesch, W
通过基质传感进行血小板产生的新路径。
影响因子：
10.1
作者：
Abbonante V;Di Buduo CA;Gruppi C;De Maria C;Spedden E;De Acutis A;Staii C;Raspanti M;Vozzi G;Kaplan DL;Moccia F;Ravid K;Balduini A
通讯作者：
Balduini A
DOI：
10.1056/nejmoa1602812
发表时间：
2016-10-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
Chesler AT;Szczot M;Bharucha-Goebel D;Čeko M;Donkervoort S;Laubacher C;Hayes LH;Alter K;Zampieri C;Stanley C;Innes AM;Mah JK;Grosmann CM;Bradley N;Nguyen D;Foley AR;Le Pichon CE;Bönnemann CG
通讯作者：
Bönnemann CG
影响因子：
4.1
作者：
Bornstein, Paul
通讯作者：
Bornstein, Paul
影响因子：
13.6
作者：
Choi JS;Harley BA
通讯作者：
Harley BA