Amperometric biosensor based on nanoporous nickel/boron-doped diamond film for electroanalysis of L-alanine
Amperometric biosensor based on nanoporous nickel/boron-doped diamond film for electroanalysis of L-alanine
复制标题
基于纳米多孔镍/硼掺杂金刚石膜的电流生物传感器用于L-丙氨酸的电分析
DOI：
10.1016/j.snb.2014.05.005
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发表时间：
2014-10-01
影响因子：
8.4
通讯作者：
Yang, Baohe
中科院分区：
文献类型：
--
作者：
Dai, Wei;Li, Mingji;Yang, Baohe
提出了一种基于纳米多孔镍修饰硼掺杂金刚石电极的L-丙氨酸电化学生物传感器。采用电子辅助热灯丝化学气相沉积法制备了自支撑BDD薄膜。电化学研究表明，NP-Ni/BDD电极上氧化还原部分的表面浓度增加导致高的电子传输和改善的传感性能。NP-Ni/BDD电极的电化学响应与L-丙氨酸浓度呈线性关系，线性范围为0.5 ~ 4.5 μ M，检测限为0.01 μ M，灵敏度为0.05 μ A μ M-1 cm（-2），回归系数为0.998。该传感器具有良好的抗干扰能力、稳定性和重现性。(C)2014爱思唯尔有限公司版权所有。
This paper presents an electrochemical biosensor for the detection of L-alanine based on a nanoporous (NP) nickel (Ni)-modified boron-doped diamond (BDD) electrode. Self-supporting BDD films are prepared using an electron-assisted hot filament chemical vapor deposition method. Electrochemical studies show that increased surface concentration of redox moieties on the NP-Ni/BDD electrode leads to high electron transport and improved sensing performance. The electrochemical response of the NP-Ni/BDD electrode as a function of L-alanine concentration exhibits a linear range from 0.5 to 4.5 mu M, and a detection limit of 0.01 mu M at a sensitivity of 0.05 mu A mu M-1 cm(-2) and a regression coefficient of 0.998. Furthermore, the proposed biosensor also showed high anti-interference ability, excellent stability and good reproducibility. (C) 2014 Elsevier B.V. All rights reserved.