The incidence of venous thromboembolism and practice of deep venous thrombosis prophylaxis in hospitalized cirrhotic patients.
The incidence of venous thromboembolism and practice of deep venous thrombosis prophylaxis in hospitalized cirrhotic patients.
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DOI：
10.1186/1477-9560-9-1
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发表时间：
2011-01-18
影响因子：
3.1
通讯作者：
Felemban A
中科院分区：
文献类型：
--
作者：
Aldawood A;Arabi Y;Aljumah A;Alsaadi A;Rishu A;Aldorzi H;Alqahtani S;Alsultan M;Felemban A
肝硬化患者的特征是凝血和抗凝因子的合成减少。抗凝患者的凝血功能障碍被认为是自身抗凝。我们的目的是确定静脉血栓栓塞症（VTE）的发病率和预测因素，并检查住院患者中深静脉血栓形成（DVT）预防的实践。在一家三级教学医院进行了一项回顾性队列研究。我们纳入了2009年1月1日至2009年12月31日期间诊断为肝硬化的所有住院成人患者。我们将我们的队列患者分为两组，无静脉血栓栓塞的血栓患者和血栓伴静脉血栓栓塞的血栓患者。在一年多的时间里，我们纳入了226例阿尔茨海默病患者，两组患者的临床和实验室参数及其结局特征相似。6例患者（2.7%）发生VTE，所有VTE均为DVT。丙型肝炎是肝硬化最常见的潜在原因（51%），其次是B型肝炎（22%）; 76%的肝硬化患者未接受药物或机械DVT预防。肝硬化患者有发生静脉血栓栓塞的风险。DVT预防的利用是次优的。
Cirrhotic patients are characterized by a decreased synthesis of coagulation and anticoagulation factors. The coagulopathy of cirrhotic patients is considered to be auto-anticoagulation. Our aim was to determine the incidence and predictors of venous thromboembolism (VTE) and examine the practice of deep venous thrombosis (DVT) prophylaxis among hospitalized cirrhotic patients. A retrospective cohort study was performed in a tertiary teaching hospital. We included all adult patients admitted to the hospital with a diagnosis of liver cirrhosis from January 1, 2009 to December 31, 2009. We grouped our cohort patients in two groups, cirrhotic patients without VTE and cirrhotic with VTE. Over one year, we included 226 cirrhotic patients, and the characteristics of both groups were similar regarding their clinical and laboratory parameters and their outcomes. Six patients (2.7%) developed VTE, and all of the VTEs were DVT. Hepatitis C was the most common (51%) underlying cause of liver cirrhosis, followed by hepatitis B (22%); 76% of the cirrhotic patients received neither pharmacological nor mechanical DVT prophylaxis. Cirrhotic patients are at risk for developing VTE. The utilization of DVT prophylaxis was suboptimal.