Facial motor neuron migration advances.
Facial motor neuron migration advances.
复制标题
面部运动神经元迁移取得进展。
DOI：
10.1016/j.conb.2013.09.001
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发表时间：
2013
影响因子：
5.7
通讯作者：
Prince,VictoriaE
中科院分区：
文献类型：
--
作者：
Wanner,SarahJ;Saeger,Ivan;Guthrie,Sarah;Prince,VictoriaE
面部分支运动神经元通过脊椎动物后脑切向迁移。遗传学和影像学为FBM神经元迁移过程提供了新的见解。平面细胞极性在神经元迁移中既有内在的作用，也有外在的作用。预先铺设的轴突束为FBM神经元的迁移提供了结构线索。老鼠和斑马鱼都有迁移，但机制细节不同。在发育过程中，特定神经元亚型的迁移是正确建立神经回路所必需的。在小鼠和斑马鱼中，面部分支运动（FBM）神经元从菱形脑4向尾侧通过后脑进行切向迁移。该领域的最新进展是利用斑马鱼和老鼠的基因研究，以及斑马鱼的高分辨率延时成像。平面细胞极性信号已成为FBM神经元迁移的一个关键保守因素，在神经元及其环境中都起作用。在斑马鱼中，迁移依赖于专门的“先锋”神经元引导跟随的FBM神经元通过后脑，并依赖于结构成分的相互作用，包括预先铺设的轴突束和基底膜。尽管有基本的保护，但在迁徙机制方面的物种特异性差异正在被发现。
HighlightsFacial branchiomotor neurons migrate tangentially through the vertebrate hindbrain.Genetics and imaging are providing new insights into FBM neuron migration processes.Planar cell polarity plays both intrinsic and extrinsic roles in neuron migration.Pre-laid axon tracts provide structural cues for FBM neurons to migrate along.Migration occurs in both mouse and zebrafish, but mechanistic details differ.During development, the migration of specific neuronal subtypes is required for the correct establishment of neural circuits. In mice and zebrafish, facial branchiomotor (FBM) neurons undergo a tangential migration from rhombomere 4 caudally through the hindbrain. Recent advances in the field have capitalized on genetic studies in zebrafish and mouse, and high-resolution time-lapse imaging in zebrafish. Planar cell polarity signaling has emerged as a critical conserved factor in FBM neuron migration, functioning both within the neurons and their environment. In zebrafish, migration depends on specialized ‘pioneer’neurons to lead follower FBM neurons through the hindbrain, and on interactions with structural components including pre-laid axon tracts and the basement membrane. Despite fundamental conservation, species-specific differences in migration mechanisms are being uncovered.