SELECTIVE ACTION OF HYDROCORTISONE ON POSTMITOTIC EPIDERMAL-CELLS INVIVO
SELECTIVE ACTION OF HYDROCORTISONE ON POSTMITOTIC EPIDERMAL-CELLS INVIVO
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DOI：
10.1111/1523-1747.ep12482145
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发表时间：
1976-01-01
影响因子：
6.5
通讯作者：
CHRISTOPHERS, E
中科院分区：
文献类型：
--
作者：
LAURENCE, EB;CHRISTOPHERS, E
通过放射自显影法测定，氢化可的松全身给药3周对小鼠表皮细胞增殖的任何阶段均无影响。细胞分化（成熟）的速度加快，由于表皮细胞寿命缩短，导致活表皮变薄。比较在饮用水中每天接受2.4 μ g/g体重的氢化可的松3周的小鼠的2个身体部位（耳朵和脚底）的表皮，显示用[3 H]胸苷标记、有丝分裂指数或细胞周期阶段的长度没有变化。表皮细胞室的定量显示，用氢化可的松使表皮变薄是由于从两个身体部位每单位表面损失相同数量的分化表皮细胞。在这两个网站有相同的有丝分裂后细胞的成熟率增加，而增殖细胞池仍然对激素无反应。改变表皮细胞成熟的速度是氢化可的松的主要作用。表皮细胞浓度，和敏感性，激素是相同的耳朵和脚底，尽管不同的速度周转的2个组织。
Hydrocortosine administered systemically for 3 wk to mice has no effect on any phase of epidermal cell proliferation as measured by autoradiographic methods. The speed of cell differentiation (maturation) is increased, resulting in a thinning of the living epidermis due to the shorter epidermal cell life. Comparison of the epidermis from 2 body sites (ear and sole of foot) in mice receiving 2.4 .mu.g/g body weight per day of hydrocortisone in drinking water for 3 wk revealed no change in the labeling with [3H]thymidine, the mitotic indices, or the lengths of the cell cycle phases. Quantitation of the epidermal cell compartments showed that thinning of the epidermis with hydrocortisone was due to the loss of an identical number of differentiating epidermal cell per unit surface from both body sites. In both sites there was the same increased rate of maturation of postmitotic cells while the proliferative cell-pool remained unresponsive to the hormone. The alteration of the speed of cell maturation is the principal action of hydrocortisone in epidermis. The epidermal cellular concentration of, and the susceptibility to, the hormone were identical in ear and sole of foot despite the differing speeds of turnover of the 2 tissues.