CSF amyloid β42 and tau levels correlate with AIDS dementia complex
CSF amyloid β42 and tau levels correlate with AIDS dementia complex
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DOI：
10.1212/01.wnl.0000183293.95787.b7
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发表时间：
2005-11-08
期刊：
影响因子：
9.9
通讯作者：
Hagberg, L
中科院分区：
文献类型：
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作者：
Brew, BJ;Pemberton, L;Hagberg, L
值得关注的是，艾滋病痴呆综合征（ADC）可能并发阿尔茨海默病（AD）。由于AD的存在和风险与CSF β-淀粉样蛋白（（1-42））（A β 42）、总tau（t-tau）和磷酸化tau（p-tau）相关，作者在ADC、AD和对照组中检查了这些。与AD相似，ADC显著降低CSF A β 42，增加t-tau和p-tau浓度，表明ADC可能与AD或AD样过程相关。
There is concern that AIDS dementia complex (ADC) may be complicated by Alzheimer disease (AD). Because AD presence and risk are related to CSF beta-amyloid((1-42)) (A beta 42), total tau (t-tau), and phosphorylated tau (p-tau), the authors examined these in ADC, AD, and controls. ADC had significantly decreased CSF A beta 42 and increased t-tau and p-tau concentrations similar to AD, suggesting that ADC may be associated with AD or an AD-like process.