The role of the cannabinoid system in nicotine addiction
The role of the cannabinoid system in nicotine addiction
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DOI：
10.1016/j.pbb.2005.01.025
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发表时间：
2005-06-01
影响因子：
3.6
通讯作者：
Maldonado, R
中科院分区：
文献类型：
--
作者：
Castañé, A;Berrendero, F;Maldonado, R
尼古丁是烟草烟雾中的主要精神活性成分，似乎在烟草成瘾中起主要作用，在世界上造成高发病率和死亡率。大量的研究已经发展到阐明参与这种复杂的成瘾行为的神经通路和神经递质系统。一个可能的候选者是大麻素系统，据报道，它参与了其他滥用药物的成瘾特性。本文综述了最近评估大麻素-尼古丁相互作用的药理学和分子研究，特别注意评估与尼古丁成瘾发展相关的行为反应的研究。(c)2005年爱思唯尔公司All rights reserved.
Nicotine, the main psychoactive component in tobacco smoke, appears to play a major role in tobacco addiction, producing a high morbidity and mortality in the world. A great amount of research has been developed to elucidate the neural pathways and neurotransmitter systems involved in such a complex addictive behaviour. One possible candidate is the cannabinoid system, which has been reported to participate in the addictive properties of other drugs of abuse. This review is focused on the recent pharmacological and molecular studies assessing cannabinoid-nicotine interactions, with special attention to those studies evaluating the behavioural responses related to the development of nicotine addiction. (c) 2005 Elsevier Inc. All rights reserved.