ICAM-1 expression on immune cells in chronic villitis
ICAM-1 expression on immune cells in chronic villitis
复制标题
DOI：
10.1016/j.placenta.2014.10.004
复制
发表时间：
2014-12-01
期刊：
影响因子：
3.8
通讯作者：
Altemani, A. M.
中科院分区：
文献类型：
--
作者：
Egal, E. S. A.;Mariano, F. V.;Altemani, A. M.
简介：无论绒毛炎病因如何，绒毛合体滋养层 (ST) 上的 ICAM-1 表达被认为参与母体细胞迁移到发炎绒毛中。然而，其在慢性绒毛炎（CV）免疫细胞上的表达仍有待分析。 ICAM-1 诱导细胞粘附，从而实现细胞间通讯、T 细胞介导的防御机制和炎症反应。材料和方法：使用 ICAM-1 分析 21 例 CV 病例（均无可识别的病原体）和 3 例对照胎盘，并分析免疫细胞 CD45、CD3 和 CD68。这些细胞根据它们在发炎绒毛中的位置进行细分：a) 发炎绒毛内，b) 外部形成绒毛周聚集体。结果：在发炎绒毛内发现大量 CD45、CD3 和 CD68，并形成附着于滋养层丧失区域的绒毛周聚集体。发炎的绒毛通常显示 ICAM-1+ ST。滋养层破裂区域周围的大多数免疫细胞呈现出 ICAM-1 的显着表达。相反，发炎绒毛内的少量免疫细胞表现出 ICAM-1 表达。只有一些（
Introduction: ICAM-1 expression on the villous syncytiotrophoblast (ST) is believed to participate in migration of maternal cells into the inflamed villi regardless of villitis etiology. However, its expression on immune cells in chronic villitis (CV) has yet to be analyzed. ICAM-1 induces cell cell adhesion allowing intercellular communication, T cell-mediated defense mechanism, and inflammatory response.Material and methods: 21 cases of CV (all without an identifiable etiologic agent) and 3 control placentas were analyzed using ICAM-1, and for immune cells CD45, CD3 and CD68. These cells were subdivided according to their location in inflamed villi: a) within the inflamed villi and b) outside forming perivillous aggregates.Results: Large amounts of CD45, CD3 and CD68 were found within the inflamed villi and forming perivillous aggregates attached to areas of trophoblastic loss. Inflamed villi usually showed ICAM-1+ ST. The majority of immune cells surrounding areas of trophoblastic rupture presented marked expression of ICAM-1. In contrast, a small number of immune cells within the inflamed villi exhibited ICAM-1 expression. Only some (