Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea
Inactivating potassium currents in apical and basal turn inner hair cells from guinea-pig cochlea
复制标题
灭活豚鼠耳蜗顶端和基底转内毛细胞中的钾电流
DOI：
10.1016/j.brainres.2008.06.068
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发表时间：
2008
期刊：
影响因子：
2.9
通讯作者：
S. Komune
中科院分区：
文献类型：
--
作者：
T. Kimitsuki;Ayako Nawate;Y. Kakazu;N. Matsumoto;Kazutaka Takaiwa;N. Komune;T. Noda;S. Komune
耳蜗内毛细胞对四乙胺(TEA)敏感的钾电流具有快速失活动力学。分别从豚鼠的顶回和基转分离IHC，并研究失活动力学的张力梯度。在心尖和基础IHC中，TEA敏感性钾电流显示失活阶段的电压依赖性时间常数，但失活程度(与稳态电流与初始峰电流之比)不依赖于电压。基础IHC的失活时间常数快于心尖IHC，失活程度大于心尖IHC，提示基础IHC的失活程度高于心尖IHC。
Tetraethylammonium (TEA)-sensitive potassium currents in the cochlear inner hair cells (IHCs) possess the kinetics of fast inactivation. IHCs of guinea-pigs were separately isolated from the apical and basal turns and the tonotopic gradient of inactivation kinetics was investigated. TEA-sensitive potassium currents showed voltage-dependent time constant of the inactivation phase both in apical and basal IHCs, however, the degree of inactivation (compared to the ratio between the steady-state current and initial peak current) was voltage-independent. Inactivation time constant was faster in basal IHCs than in apical IHCs and the degree of inactivation was greater in basal IHCs than in apical IHCs, suggesting that inactivation was more predominant in basal IHCs than in apical IHCs.
影响因子：
3.4
作者：
Ding, JP;Li, ZW;Lingle, CJ
通讯作者：
Lingle, CJ
影响因子：
2.5
作者：
Skinner, LJ;Enée, V;Dulon, D
通讯作者：
Dulon, D