Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis
Quantitative assessment of MRI T2 relaxation time of thigh muscles in juvenile dermatomyositis
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DOI：
10.1093/rheumatology/keh130
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发表时间：
2004-05-01
期刊：
影响因子：
5.5
通讯作者：
Murray, KJ
中科院分区：
文献类型：
--
作者：
Maillard, SM;Jones, R;Murray, KJ
Objective.本研究的目的是探讨在幼年型皮肌炎（JDM）患儿中使用磁共振成像（MRI）进行炎症定量测量的有效性和可靠性。患有活动性JDM的儿童、非活动性JDM的儿童和健康儿童接受了对公认的肌肉炎症指标（包括肌肉力量）的详细评估（手动肌肉测试和肌测量）和功能（儿童肌炎评估量表，儿童健康评估问卷），肌肉酶乳酸脱氢酶（LDH）和肌酸激酶（CK）以及大腿肌肉的T-2加权MRI扫描，并将这些值进行相关分析。10名活动性JDM儿童，10名非活动性JDM儿童和20名健康儿童完成了研究。三组之间的年龄没有显著差异。与非活动性JDM和健康儿童相比，活动性JDM的MRI T-2弛豫时间显著增加（P = 0.05），表明肌肉内炎症的可检测增加。MRI评分与肌肉力量和功能指标之间也有良好的相关性;然而，MRI与肌肉酶之间没有相关性。MRI T-2弛豫时间可用作肌肉炎症的定量测量，并且与疾病活动的其他测量具有良好的相关性。
Objective. The aim of the study was to examine the validity and reliability of a quantifiable measure of inflammation using magnetic resonance imaging (MRI) in children with juvenile dermatomyositis (JDM).Methods. Children with active JDM, inactive JDM and healthy children received detailed assessments of recognized measures of muscle inflammation including muscle strength (manual muscle testing and myometry) and function (Childhood Myositis Assessment Scale, Childhood Health Assessment Questionnaire), the muscle enzymes lactate dehydrogenase (LDH) and creatine kinase (CK) and T-2-weighted MRI scans of the thigh muscles, and these values were correlated with each other.Results. Ten children with active JDM, 10 with inactive JDM and 20 healthy children completed the study. There was no significant difference in ages between the three groups. The MRI T-2 relaxation times were significantly increased in active JDM compared with inactive JDM and healthy children (P = 0.05), indicating a detectable increase in inflammation within the muscles. There were also good correlations between the MRI scores and the measures of muscle strength and function; however, there was no correlation between the MRI and muscle enzymes.Conclusions. The MRI T-2 relaxation time can be used as a quantitative measure of muscle inflammation and it has good correlations with other measures of disease activity.