A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds
A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds
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DOI：
10.1039/c3dt52524d
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发表时间：
2014-01-01
影响因子：
4
通讯作者：
Casini, Angela
中科院分区：
文献类型：
--
作者：
Bertrand, Benoit;Casini, Angela
从手指上的结婚戒指到彩色玻璃窗，再到奥运奖牌，黄金几千年来一直受到高度重视。金属有机金化合物因其独特的化学性质而在药物无机化学领域占有重要地位。事实上，几项研究已经证明，它们可以用于开发高效的金属基药物，可能用于治疗癌症。该观点总结了不同家族的生物活性有机金属金化合物，包括环化的金（III）配合物与C，N-供体配体，金（I）和金（I/III）N-杂环（NHC）卡宾配合物，以及金（I）炔基配合物，具有良好的抗癌效果。最重要的是，我们将专注于该领域的最新发展，并讨论这类有机金属化合物在其多功能化学和创新作用机制方面的潜力。
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an important place in the field of medicinal inorganic chemistry due to their unique chemical properties with respect to gold coordination compounds. In fact, several studies have proved that they can be used to develop highly efficient metal-based drugs with possible applications in the treatment of cancer. This Perspective summarizes the results obtained for different families of bioactive organometallic gold compounds including cyclometallated gold(III) complexes with C, N-donor ligands, gold(I) and gold(I/III) N-heterocyclic (NHC) carbene complexes, as well as gold(I) alkynyl complexes, with promising anticancer effects. Most importantly, we will focus on recent developments in the field and discuss the potential of this class of organometallic compounds in relation to their versatile chemistry and innovative mechanisms of action.