LOSS OF PERFORATED SYNAPSES IN THE DENTATE GYRUS - MORPHOLOGICAL SUBSTRATE OF MEMORY DEFICIT IN AGED RATS
LOSS OF PERFORATED SYNAPSES IN THE DENTATE GYRUS - MORPHOLOGICAL SUBSTRATE OF MEMORY DEFICIT IN AGED RATS
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DOI：
10.1073/pnas.83.9.3027
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发表时间：
1986-05-01
影响因子：
11.1
通讯作者：
MORRELL, F
中科院分区：
文献类型：
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作者：
GEINISMAN, Y;DETOLEDOMORRELL, L;MORRELL, F
大多数（但不是全部）老年大鼠在放射状迷宫中测试时表现出严重的空间记忆缺陷——已知这项任务取决于海马结构的完整性。在这项研究中，根据动物的空间记忆能力将其分为三组：记忆良好的年轻成年大鼠、记忆受损的老年大鼠和记忆良好的老年大鼠。与记忆力良好的年轻成年或老年大鼠相比，记忆受损的老年动物在海马齿状回中表现出穿孔轴突突触的丧失。这一发现表明，海马结构中穿孔轴棘突触的丧失是与年龄相关的空间记忆缺陷的基础。
Most, but not all, aged rats exhibit a profound deficit in spatial memory when tested in a radial maze-a task known to depend on the integrity of the hippocampal formation. In this study, animals were divided into three groups based on their spatial memory capacity: young adult rats with good memory, aged rats with impaired memory, and aged rats with good memory. Memory-impaired aged animals showed a loss of perforated axospinous synapses in the dentate gyrus of the hippocampal formation in comparison with either young adults or aged rats with good memory. This finding suggests that the loss of perforated axospinous synapses in the hippocampal formation underlies the age-related deficit in spatial memory.